Anti-LRRK1 Antibody (N341/12)

Name: Anti-LRRK1 Antibody
Brand: NeuroMab
SKU: 75-347
Price: 319.0 USD
Availability: InStock

Our Anti-LRRK1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N341/12. It is KO validated, detects human and mouse LRRK1, and is purified by Protein A chromatography. It is great for use in ICC, WB.

Immunoblot versus LRRK1-immunoprecipitated extracts from WT and LRRK1 KO mouse heart probed with N341/12 TC supe. Data courtesy of Paul Davies and Dario Alessi (University of Dundee, Scotland, UK.

Transfected cell immunoblot: extracts of COS cells transiently transfected with Myc-tagged LRRK1, LRRK2 or untagged Kv2.1 plasmid and probed with N341/12 (left) or N241A/34 (right) TC supe.

Species Reactivity

Human, Mouse

Applications

ICC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

KO Validated

SKU: 75-347

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

LRRK1

Target Description

Leucine Rich Repeat Kinase 1 is encoded by the gene LRRK1. LRRK1 is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, ROCO subfamily. LRRK1 is a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. LRRK1 is thought to play a role in the regulation of bone mass. LRRK1 is overexpressed in lymph node and uterus. Diseases associated with LRRK1 include Osteosclerotic Metaphyseal Dysplasia and Parkinson Disease 3, Autosomal Dominant.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N341/12

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

LRRK1 KIAA1790

Molecular Weight

>200 kDa

Antigen

Fusion protein amino acids 1695-2015 (C-terminus) of human LRRK1 (accession number Q38SD2) produced recombinantly in E. Coli.

Species Reactivity

Human, Mouse

Antibody Registry ID

AB_2315880

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with LRRK2

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)

UniProt Details

UniProt (Human): Q38SD2
UniProt (Immunogen Species): Q38SD2

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Anti-LRRK1 Antibody (N341/12)

SKU: 75-347

Product Details

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