Our Anti-Malin mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N85/18. It detects human, mouse, non-human primate, rat Malin, and is purified by Protein A chromatography. It is great for use in ICC, WB.
Immunoblot against extracts of COS cells transiently transfected with Flag-tagged Malin or untagged Kv2.1 plasmid probed with N85/18 TC supe (left) or rabbit polyclonal (right).
NHL Repeat Containing E3 Ubiquitin Protein Ligase 1 is encoded by the gene NHLRC1. NHLRC1 is an E3 ubiquitin-protein ligase which is involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. NHLRC1 is expressed in the brain, spinal cord, heart, liver, skeletal muscle, and pancreas. Diseases associated with NHLRC1 include Myoclonic Epilepsy of Lafora and Epilepsy.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N85/18
IgG1
ICC, WB
Mouse
NHLRC1 EPM2B
42 kDa
Fusion protein amino acids 1-395 (full-length) of human malin (accession number AAQ19671) produced recombinantly in E. Coli
Human, Mouse, Non-Human Primate, Rat
AB_2153100
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.55
Unconjugated
No cross-reactivity reported
Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Sengupta, S., et al. 2011. Malin and laforin are essential components of a protein complex that protects cells from thermal stress.. Journal of Cell Science, 2277-86.
Sánchez-Martín, P., et al. 2015. Ubiquitin conjugating enzyme E2-N and sequestosome-1 (p62) are components of the ubiquitination process mediated by the malin-laforin E3-ubiquitin ligase complex.. The International Journal of Biochemistry & Cell Biology, 204-14.
Upadhyay, M., et al. 2017. Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models.. Neurobiology of Disease, 39-51.
Sengupta, S., et al. 2011. Malin and laforin are essential components of a protein complex that protects cells from thermal stress.. Journal of Cell Science, 2277-86.
Sengupta, S., et al. 2011. Malin and laforin are essential components of a protein complex that protects cells from thermal stress.. Journal of Cell Science, 2277-86.
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