Anti-Neurexin-1-Beta (Staining) Antibody (N170A/1)

Our Anti-Neurexin-1-Beta (staining) mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N170A/1. It detects human and mouse Neurexin-1-Beta (staining), and is purified by Protein A chromatography. It is great for use in ICC, WB.



SKU: 75-216

Volume: 100 µL
Price:
Sale price$385.00
Ships: 1-2 business days

Product Details

Neurexin-1-Beta (staining)
Neurexin-1Beta is a member of the neurexin family. Neurexin-1Beta is a membrane bound receptor and binds neuroligins and forms complexes at neuronal synapses in the central nervous system. Binding parterns for Neurexin 1beta include CASK, Neuroligins 1-3 and DAG1. Neurexin-1Beta serves as a presynaptic marker and plays an important role in assembling presynaptic and postsynaptic machinery. This protein may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins and possibly plays a role in synaptic junctions formation or maintenance.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N170A/1
IgG1
ICC, WB
Mouse
NRXN1
50 kDa
Synthetic peptide amino acids 47-64 (ASSLGAHHIHHFHGSSKH, extracellular N-terminus) of rat Neurexin-1-Beta (accession number Q63373)
Human, Mouse
AB_2155531
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Unconjugated
Does not cross-react with Neurexin-2-Beta
Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
Neurexin-1-beta (Neurexin I-beta)

Product Specific References for Applications and Species

Flow Cytometry: Mouse
PMID Dilution Publication
331856032.5 ug/mLSingh, A., et al. 2020. Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer’s Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers. Journal of Alzheimers Disease, .
316858652.5ug/mlForner, S., et al. 2019. Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus. Scientific Reports, 15936.
279869242.5ug/mlPrieto, G.A., et al. 2017. Pharmacological Rescue of Long-Term Potentiation in Alzheimer Diseased Synapses. Journal of Neuroscience, 1197-1212.
Flow Cytometry: Rat
PMID Dilution Publication
263059681:400Prieto, G.A., et al. 2015. Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus. PNAS USA, E5078-E5087.
Immunocytochemistry: Mouse
PMID Dilution Publication
296196142.5ug/mlPrieto, G.A., et al. 2019. TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse. Neurochemistry Research, 49-60.
Immunocytochemistry: Non-Human Primate
PMID Dilution Publication
37048156not listedFeller, B., et al. 2023. α-Synuclein Preformed Fibrils Bind to β-Neurexins and Impair β-Neurexin-Mediated Presynaptic Organization. Cells, 1083.
Immunocytochemistry: Rat
PMID Dilution Publication
29760652not listedYamagata, M., et al. 2018. Cadherins Interact With Synaptic Organizers to Promote Synaptic Differentiation.. Frontiers in Molecular Neuroscience, 142.
234266881:1000Futai, K., et al. 2013. Specific trans-synaptic interaction with inhibitory interneuronal neurexin underlies differential ability of neuroligins to induce functional inhibitory synapses.. Journal of Neuroscience, 3612-3623.
Immunohistochemistry: Mouse
PMID Dilution Publication
22355283not listedYamagata, M., et al. 2012. Transgenic strategy for identifying synaptic connections in mice by fluorescence complementation (GRASP).. Frontiers in Molecular Neuroscience, 18.
Western Blot: Human
PMID Dilution Publication
23536886not listedZeng, L., et al. 2013. Functional impacts of NRXN1 knockdown on neurodevelopment in stem cell models. PLoS One, e59685.
Western Blot: Mouse
PMID Dilution Publication
390135261:1000Currie, J., et al. 2024. Using FASS-LTP in postmortem mice brain tissues to assess pathological synaptic function. Journal of Neuroscience Methods, 110219.
341339201:500Klatt, O., et al. 2021. Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior.. Cell Reports, 109266.
Western Blot: Non-Human Primate
PMID Dilution Publication
36697254not listedLee, A.K., et al. 2023. SorCS1 inhibits amyloid-β binding to neurexin and rescues amyloid-β-induced synaptic pathology. Life Science Alliance, e202201681.
Additional Publications: Unspecified
PMID Publication
30707832Jeon, J., et al. 2019. Robust Induced Presynapse on Artificial Substrates as a Neural Interfacing Method. ACS Applied Materials and Interfaces, 7764-7773.
25428619Fang, M., et al. 2016. Neuroligin-1 Knockdown Suppresses Seizure Activity by Regulating Neuronal Hyperexcitability. Molecular Neurobiology, 270-284.

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