Anti-Neuropeptide Y Antibody (L115/13)

Name: Anti-Neuropeptide Y Antibody
Brand: NeuroMab
SKU: 75-456
Price: 319.0 USD
Availability: InStock

1 Citation

Our Anti-Neuropeptide Y mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L115/13. It detects human, mouse, and rat Neuropeptide Y, and is purified by Protein A chromatography. It is great for use in AT, IHC, ICC.

Array tomography immunofluorescence of Lowicryl-embedded sections from adult mouse cortex layer 2/3 with L115/13 (green), GABA (red) and DAPI (blue). Volume reconstruction of 35 serial 70 nm sections show two NPY-positive neurons with varying levels of GABA reactivity, as well as some NPY-reactive axonal varicosities. Images courtesy of Kristina Micheva (Stanford).

Adult rat hippocampus immunohistochemistry.

Array tomography immunofluorescence of Lowicryl-embedded sections from adult mouse cortex layer 2/3 with L115/13 (green), GABA (red) and DAPI (blue). Volume reconstruction of 35 serial 70 nm sections show two NPY-positive neurons with varying levels of GABA reactivity, as well as some NPY-reactive axonal varicosities. Images courtesy of Kristina Micheva (Stanford).

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-456

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

Neuropeptide Y

Target Description

Neuropeptide Y is encoded by the gene NPY. NPY is a member of the NPY family. NPY is a neuropeptide that influences many physiological processes including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. NPY functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. NPY is widely expressed in the central nervous system. Diseases associated with NPY include Eating Disorder and Adjustment Disorder.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L115/13

Isotype

IgG2a

Applications

ICC, IHC

Host Species

Mouse

Gene Name

NPY

Molecular Weight

11 kDa

Antigen

Fusion protein amino acids 28-97 (all but signal peptide) of human NPY (accession number P01303) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2651168

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]

UniProt Details

UniProt (Human): P01303
UniProt (Immunogen Species): P01303

Product Specific References for Applications and Species

Immunohistochemistry: Mouse

Immunohistochemistry: Mouse
PMID	Dilution	Publication
39103318	1:200	Han, X., et al. 2024. Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex. Nature Communications, 6648.

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Anti-Neuropeptide Y Antibody (L115/13)

SKU: 75-456

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-Neuropeptide Y Antibody

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