Anti-PARIS/ZNF746 Antibody (N196/16)
Our Anti-PARIS/ZNF746 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N196/16. It detects human, mouse, and rat PARIS/ZNF746, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
![Immunoblot versus crude brain membranes from adult mouse (MBM), rat (RBM) and human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)] probed with N196/16 (left) or N52A/42 (right) TC supe.](http://www.antibodiesinc.com/cdn/shop/products/validation-image-73-195-n196-16-wb3_{width}x.jpg?v=1626904053)
Adult rat brain immunohistochemistry.
![Immunoblot versus crude brain membranes from adult mouse (MBM), rat (RBM) and human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)] probed with N196/16 (left) or N52A/42 (right) TC supe.](http://www.antibodiesinc.com/cdn/shop/products/validation-image-73-195-n196-16-wb3_1024x.jpg?v=1626904053)
Product Specific References for Applications and Species
- Co-ImmunoPrecipitation: Human
- Immunohistochemistry: Non-Human Primate
- Western Blot: Drosophila | Human | Mouse
- Additional Publications: Unspecified
| Co-Immunoprecipitation: Human | ||
| PMID | Dilution | Publication |
| 28122242 | not listed | Lee, Y., et al. 2017. PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival. Cell Reports, 918-932. |
| Immunohistochemistry: Non-Human Primate | ||
| PMID | Dilution | Publication |
| 34165772 | not listed | Li, H., et al. 2021. Co-editing PINK1 and DJ-1 genes via adeno-associated virus-delivered CRISPR/Cas9 system in adult monkey brain elicits classical parkinsonian phenotype.. Neuroscience bulletin, 1271-1288. |
| Western Blot: Drosophila | ||
| PMID | Dilution | Publication |
| 32138754 | 1:2000 | Pirooznia, S.K., et al. 2020. PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency. Molecular Neurodegeneration, 17. |
| Western Blot: Human | ||
| PMID | Dilution | Publication |
| 32795422 | not listed | Kumar, M., et al. 2020. Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons. Stem Cell Reports., 629-645. |
| 31237944 | not listed | Brahmachari, S., et al. 2019. Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease. Brain, 2380-2401. |
| 25099937 | 1:1000 | Liu, Z., et al. 2014. Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cells.. PLoS One, e104247. |
| 23740939 | 1:1000 | Silva, D.F., et al. 2013. Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines.. Human Molecular Genetics, 3931-3946. |
| 21825151 | not listed | Kang, H.C., et al. 2011. Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.. PNAS USA, 14103-14108. |
| Western Blot: Mouse | ||
| PMID | Dilution | Publication |
| 31237944 | not listed | Brahmachari, S., et al. 2019. Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease. Brain, 2380-2401. |
| 30126943 | 1:1000 | Palomo, G.M., et al. 2018. Parkin is a disease modifier in the mutant SOD1 mouse model of ALS. EMBO Molecular Medicine, e8888. |
| Additional Publications: Unspecified | ||
| PMID | Publication | |
| 38159138 | McKiel, A., et al. 2024. Post-activation potentiation and potentiated motor unit firing patterns in boys and men. European Journal of Applied Physiology, 1561-1574. | |
| 28939041 | Kim, H., et al. 2017. Identification of transketolase as a target of PARIS in substantia nigra. Biochemical and Biophysical Research Communications, 1050-1056. | |