Anti-PARIS/ZNF746 Antibody (N196/16)

Our Anti-PARIS/ZNF746 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N196/16. It detects human, mouse, and rat PARIS/ZNF746, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.



SKU: 75-195

Volume: 100 µL
Price:
Sale price$329.00
Ships: 1-2 business days

Product Details

PARIS/ZNF746
Zinc finger protein 746, Parkin-Interacting Substrate or PARIS/ZNF746 is encoded by the gene ZNF746. PARIS is a transcription repressor that binds to a consensus sequence on promoters and represses the expression of a transcriptional coactivator, PGC-1-alpha (PPARGC1A). This protein plays a role in regulation of neuron death. PARIS is found in the cytoplasm and nucleus
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N196/16
IgG1
ICC, IHC, WB
Mouse
ZNF746 PARIS
60-70 kDa
Fusion protein amino acids 1-322 (N-terminus) of human ZNF746 (accession number Q6NUN9) produced recombinantly in E. Coli
Human, Mouse, Rat
AB_10674714
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.123
Unconjugated
Does not cross-react with ZNF783 or ZNF398
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
Zinc finger protein 746 (Parkin-interacting substrate) (PARIS)

Product Specific References for Applications and Species

Co-Immunoprecipitation: Human
PMID Dilution Publication
28122242not listedLee, Y., et al. 2017. PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival. Cell Reports, 918-932.
Immunohistochemistry: Non-Human Primate
PMID Dilution Publication
34165772not listedLi, H., et al. 2021. Co-editing PINK1 and DJ-1 genes via adeno-associated virus-delivered CRISPR/Cas9 system in adult monkey brain elicits classical parkinsonian phenotype.. Neuroscience bulletin, 1271-1288.
Western Blot: Drosophila
PMID Dilution Publication
321387541:2000Pirooznia, S.K., et al. 2020. PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency. Molecular Neurodegeneration, 17.
Western Blot: Human
PMID Dilution Publication
32795422not listedKumar, M., et al. 2020. Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons. Stem Cell Reports., 629-645.
31237944not listedBrahmachari, S., et al. 2019. Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease. Brain, 2380-2401.
250999371:1000Liu, Z., et al. 2014. Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cells.. PLoS One, e104247.
237409391:1000Silva, D.F., et al. 2013. Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines.. Human Molecular Genetics, 3931-3946.
21825151not listedKang, H.C., et al. 2011. Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.. PNAS USA, 14103-14108.
Western Blot: Mouse
PMID Dilution Publication
31237944not listedBrahmachari, S., et al. 2019. Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease. Brain, 2380-2401.
301269431:1000Palomo, G.M., et al. 2018. Parkin is a disease modifier in the mutant SOD1 mouse model of ALS. EMBO Molecular Medicine, e8888.
Additional Publications: Unspecified
PMID Publication
38159138McKiel, A., et al. 2024. Post-activation potentiation and potentiated motor unit firing patterns in boys and men. European Journal of Applied Physiology, 1561-1574.
28939041Kim, H., et al. 2017. Identification of transketolase as a target of PARIS in substantia nigra. Biochemical and Biophysical Research Communications, 1050-1056.

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