Anti-Parvalbumin Antibody (L114/81)

Name: Anti-Parvalbumin Antibody
Brand: NeuroMab
SKU: 75-479
Price: 319.0 USD
Availability: InStock

Our Anti-Parvalbumin mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L114/81. It detects mouse and rat Parvalbumin, and is purified by Protein A chromatography. It is great for use in AT, IHC, ICC, WB.

Adult rat somatosensory cortex immunohistochemistry.

Immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] probed with L114/81 (left) or N52A/42 (right) TC supe.

Array tomography immunofluorescence volume reconstruction of 8 serial LRWhite-embedded 70 nm sections from adult mouse cerebellum with L114/81 (green), rabbit Parvalbumin (Swant PV28, red) and DAPI (blue), with composite overlay (bottom). Images courtesy of Kristina Micheva (Stanford).

Adult rat hippocampus immunohistochemistry.

Adult rat thalamus immunohistochemistry.

Adult rat somatosensory cortex immunohistochemistry.

Species Reactivity

Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-479

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

Parvalbumin

Target Description

Parvalbumin (PA) is a classical small, mostly cytosolic Ca2+-binding protein of the EF-hand superfamily expressed in vertebrates in a tissue- and cell-specific manner, serving as a magnesium/ calcium buffer (Permyakov EA et al., 2017). Parvalbumin (PV)-expressing interneurons are a class of inhibitory neurons that fire rapid barrages of action potentials, and are accordingly named “fast-spiking” interneurons (Trachtenberg J. 2015).

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L114/81

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Pvalb Pva

Molecular Weight

20 kDa

Antigen

Fusion protein amino acids 1-110 (full-length) of rat Parvalbumin (accession number P02625) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2728742

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Parvalbumin alpha

UniProt Details

UniProt (Human): Q9H598

Product Specific References for Applications and Species

Immunohistochemistry: Mouse

Immunohistochemistry: Mouse
PMID	Dilution	Publication
39103318	1:200	Han, X., et al. 2024. Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex. Nature Communications, 6648.
37833406	not listed	Ma, D, et al. 2023. A cytoskeleton-membrane interaction conserved in fast-spiking neurons controls movement, emotion, and memory. Molecular psychiatry, .

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Anti-Parvalbumin Antibody (L114/81)

SKU: 75-479

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-Parvalbumin Antibody

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