Anti-SAPAP1/2 Antibody (N238/31)

Name: Anti-SAPAP1/2 Antibody
Brand: NeuroMab
SKU: 75-236
Price: 319.0 USD
Availability: InStock

Our Anti-SAPAP1/2 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N238/31. It detects human, mouse, and rat SAPAP1/2, and is purified by Protein A chromatography. It is great for use in ICC, WB.

Adult rat brain membrane (RBM) immunoblot.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-236

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

SAPAP1/2

Target Description

SAPAP1 (also known as disks large associated protein 1) and SAPAP2 (also known as disks large associated protein 2) are members of the SAPAP or DLGAP family of proteins. SAPAP proteins function as scaffolding proteins at excitatory synapses. SAPAP proteins interact with PSD95 family and Shank family proteins to anchor/target neurotransmitter receptors and signaling molecules to the postsynaptic membrane of excitatory synapses.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N238/31

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

DLGAP1 DAP1 GKAP DLGAP2 C8orf68 DAP2 ERICH1-AS1

Molecular Weight

110 kDa (varies due to post-translational modifications)

Antigen

Fusion protein amino acids 772-992 (C-terminus) of rat SAPAP1 (accession number P97836) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2230571

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with other SAPAPs

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Disks large-associated protein 1 (SAPAP1) SAPAP-1 Disks large-associated protein 2 (SAPAP2) SAPAP-2

UniProt Details

UniProt (Human): O14490
UniProt (Immunogen Species): P97836

Product Specific References for Applications and Species

Immunocytochemistry: Human
Western Blot: Mouse

Immunocytochemistry: Human
PMID	Dilution	Publication
31321035	not listed	Kwiatkowski, B.A., et al. 2019. DLGAP1 directs megakaryocytic growth and differentiation in an MPL dependent manner in hematopoietic cells. BiMark Research, 13.

Western Blot: Mouse
PMID	Dilution	Publication
30586380	not listed	Favaro, P.D., et al. 2018. An opposing function of paralogs in balancing developmental synapse maturation. Plos Biology, e2006838.
26527743	1:1000	Schreiber, J., et al. 2015. Ubiquitin ligase TRIM3 controls hippocampal plasticity and learning by regulating synaptic γ-actin levels.. The Journal of Biology, 569-86.
24795561	1:1000	Lugo, J.N., et al. 2014. Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins.. Frontiers in Molecular Neuroscience, 27.
23791193	1:1000	Gross, G.G., et al. 2013. Recombinant probes for visualizing endogenous synaptic proteins in living neurons.. Neuron, 971-985.

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Anti-SAPAP1/2 Antibody (N238/31)

SKU: 75-236

Product Details

Product Specific References for Applications and Species

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