Anti-SK2 potassium channel Antibody (K78/29)

Name: Anti-SK2 potassium channel Antibody
Brand: NeuroMab
SKU: 75-403
Price: 319.0 USD
Availability: InStock

1 Citation

Our Anti-SK2 potassium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K78/29. It detects human, mouse, and rat SK2 potassium channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with GFP-tagged SK1, SK3 or SK4 or untagged SK2 or Kv2.1 plasmid and probed with K78/29 (left) and N86/8 (right) TC supe.

Adult rat hippocampus immunohistochemistry.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-403

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

SK2 potassium channel

Target Description

Potassium calcium-activated channel subfamily N member 2 is encoded by the gene KCNN2. KCNN2 is a member of the potassium KCNN family, KCa2.2/KCNN2 subfamily. KCNN2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Activation of KCNN2 leads to membrane hyperpolarization. KCNN2 is expressed in the brain. Diseases associated with KCNN2 include Dyskeratosis Congenita, Autosomal Dominant 3 and Coronary Aneurysm.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K78/29

Isotype

IgG1

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnn2

Molecular Weight

50-80 kDa (and larger due to isoforms and dimerization/aggregation)

Antigen

Synthetic peptide amino acids 546-562 (ENYDKHVTYNAERSRSS, cytoplasmic C-terminus) of rat SK2 (accession number P70604)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2491099

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with other SK channels

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)

UniProt Details

UniProt (Human): Q9H2S1
UniProt (Immunogen Species): P70604

Product Specific References for Applications and Species

Immunprecipitation: Mouse

Immunoprecipitation: Mouse
PMID	Dilution	Publication
35442745	not listed	Snell, H.D., et al. 2022. Mechanism of Stress-Induced Attacks in an Episodic Neurologic Disorder. Science Advances, eabh2675.

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Anti-SK2 potassium channel Antibody (K78/29)

SKU: 75-403

Product Details

Product Specific References for Applications and Species

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