Anti-Slo1 Maxi-K+ Channel Antibody (L6/60)

126 Citations

Our Anti-Slo1 maxi-K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L6/60. It is KO validated, detects human, mouse, rat, sheep, and zebrafish Slo1 maxi-K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Immunofluorescence staining of hippocampal CA3 of adult WT and Slo1 KO mice with L6/60 (red) and Kv2.1 rabbit polyclonal (green).
Immunoblot versus crude membranes from adult rat brain (RBM) and WT and Slo1 KO mouse brains probed with L6/60 TC supe.
Western blot showing specific labeleing of BKCa/β-Actin in control and and Cinaciguat-treated lambs. Image from publication CC-BY-4.0. PMID: 35733986
Top: Adult rat hippocampus immunohistochemistry. Bottom: Immunofluorescence staining of hippocampal CA3 of adult WT and Slo1 KO mice with L6/60 (red) and Kv2.1 rabbit polyclonal (green).
Epitope mapped to within amino acids 690-715 (PKLMRHDPLLIPGNDQIDNMDSNVKK, 100% conserved in mouse, rat, human, horse, dog, pig, cow, Rhesus monkey and rabbit, indicated by arrow in image at right) by Daniel Levy (University of Chicago).
Representative images of EC PM TRPV4 and BK (green), endothelial glycoprotein marker Lectin (red) in cross-sections of large and small mesenteric arteries. Nuclei are labeled with SYTOX (blue). “NO 1°” shows the no primary Ab negative controls. Image from publication CC-BY-4.0. PMID:36139754
Representative mid-cell section of a mesenteric artery smooth muscle cell stained for wheat germ agglutinin (WGA, green), (P)RR (purple), and BKCa channel (cat. 75-022, 1:100; orange). Nucleus is stained with DAPI and shown in blue. Image from publication CC-BY-4.0. PMID:37994700
Drosophila cardiac tubes labeled with anti‐BKCa (cat. 75-022, 1:100) and wheat germ agglutinin (WGA, plasma membrane marker) isolated from wild‐type flies. (e) Cardiac tube labeled with WGA. (f) Cardiac tube labeled with anti‐BKCa. (g) Cardiac tube stained for nucleus with DAPI. (h) Merged image of (e, f) and (g, i) Enlarged region from a white box in (h) BKCa does not localize to the WGA labeled plasma membrane. Image from publication CC-BY-4.0. PMID:38561252
Drosophila cardiac tubes labeled with anti‐BKCa (cat. 75-022, 1:100) and WGA isolated from slo mutant flies. (j) Cardiac tube labeled with WGA. (k) Cardiac tube labeled with anti‐BKCa showed no significant labeling for BKCa. (l) Cardiac tube stained for nucleus with DAPI. (m) Merged image of (j, k) and (l, n) Enlarged region from a white box in m. Image from publication CC-BY-4.0. PMID:38561252
Immunofluorescence staining of hippocampal CA3 of adult WT and Slo1 KO mice with L6/60 (red) and Kv2.1 rabbit polyclonal (green).
Immunofluorescence staining of hippocampal CA3 of adult WT and Slo1 KO mice with L6/60 (red) and Kv2.1 rabbit polyclonal (green).
Immunoblot versus crude membranes from adult rat brain (RBM) and WT and Slo1 KO mouse brains probed with L6/60 TC supe.
Western blot showing specific labeleing of BKCa/β-Actin in control and and Cinaciguat-treated lambs. Image from publication CC-BY-4.0. PMID: 35733986
Top: Adult rat hippocampus immunohistochemistry. Bottom: Immunofluorescence staining of hippocampal CA3 of adult WT and Slo1 KO mice with L6/60 (red) and Kv2.1 rabbit polyclonal (green).
Epitope mapped to within amino acids 690-715 (PKLMRHDPLLIPGNDQIDNMDSNVKK, 100% conserved in mouse, rat, human, horse, dog, pig, cow, Rhesus monkey and rabbit, indicated by arrow in image at right) by Daniel Levy (University of Chicago).
Representative images of EC PM TRPV4 and BK (green), endothelial glycoprotein marker Lectin (red) in cross-sections of large and small mesenteric arteries. Nuclei are labeled with SYTOX (blue). “NO 1°” shows the no primary Ab negative controls. Image from publication CC-BY-4.0. PMID:36139754
Representative mid-cell section of a mesenteric artery smooth muscle cell stained for wheat germ agglutinin (WGA, green), (P)RR (purple), and BKCa channel (cat. 75-022, 1:100; orange). Nucleus is stained with DAPI and shown in blue. Image from publication CC-BY-4.0. PMID:37994700
Drosophila cardiac tubes labeled with anti‐BKCa (cat. 75-022, 1:100) and wheat germ agglutinin (WGA, plasma membrane marker) isolated from wild‐type flies. (e) Cardiac tube labeled with WGA. (f) Cardiac tube labeled with anti‐BKCa. (g) Cardiac tube stained for nucleus with DAPI. (h) Merged image of (e, f) and (g, i) Enlarged region from a white box in (h) BKCa does not localize to the WGA labeled plasma membrane. Image from publication CC-BY-4.0. PMID:38561252
Drosophila cardiac tubes labeled with anti‐BKCa (cat. 75-022, 1:100) and WGA isolated from slo mutant flies. (j) Cardiac tube labeled with WGA. (k) Cardiac tube labeled with anti‐BKCa showed no significant labeling for BKCa. (l) Cardiac tube stained for nucleus with DAPI. (m) Merged image of (j, k) and (l, n) Enlarged region from a white box in m. Image from publication CC-BY-4.0. PMID:38561252

Human, Mouse, Rat, Sheep, Zebrafish
ICC, IHC, IP, WB
Mouse
490
550
594
650

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Data Sheet
KO Validated KO Validated Trial Size Trial Size

SKU: 75-022

Volume: 100 µL
1-2 business days
Price:
$374.00

Product Specific References for Applications and Species

Immunocytochemistry: Drosophila
PMID Dilution Publication
385612521:100Gururaja Rao, S, et al. 2024. The BKCa (slo) channel regulates the cardiac function of Drosophila. Physiological Reports, e15996.
Immunocytochemistry: Human
PMID Dilution Publication
278720491:200Nishijima, Y., et al. 2017. Contribution of Kv1. 5 channel to hydrogen peroxide–induced human arteriolar dilation and its modulation by coronary artery disease. . Circulation research, 658-669.
27763639not listedTajhya, R.B., et al. 2016. Functional KCa1.1 channels are crucial for regulating the proliferation, migration and differentiation of human primary skeletal myoblasts. Cell Death and Disease, e2426.
Immunocytochemistry: Mouse
PMID Dilution Publication
31974459not listedSun, X., et al. 2020. A lysosomal K+ channel regulates large particle phagocytosis by facilitating lysosome Ca2+ release. Scientific Reports, 1038.
277079721:1000Lin, M., et al. 2016. Methamphetamine Regulation of Firing Activity of Dopamine Neurons. Journal of Neuroscience, 10376-10391.
Immunocytochemistry: Non-Human Primate
PMID Dilution Publication
302125311:200Bisen, S., et al. 2018. Large conductance voltage- and calcium-gated potassium channels (BK) in cerebral artery myocytes of perinatal fetal primates share several major characteristics with the adult phenotype. PLoS One, e0203199.
Immunocytochemistry: Rat
PMID Dilution Publication
379947001:100Rognant, S, et al. 2023. Acute, pro-contractile effects of prorenin on rat mesenteric arteries. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, e23282.
301812771:100Zhang, J., et al. 2018. Glutamate-activated BK channel complexes formed with NMDA receptors. PNAS, E9006-E9014.
28012000not listedKuntamallappanavar, G., et al. 2017. Differential distribution and functional impact of BK channel beta1 subunits across mesenteric, coronary, and different cerebral arteries of the rat. Pflugers Archiv: European Journal of Physiology, 263-277.
29391966not listedBukiya, A.N., et al. 2016. Age-Dependent Susceptibility to Alcohol-Induced Cerebral Artery Constriction. Journal of Drug and Alcohol Research, 236002.
Immunohistochemistry: Mouse
PMID Dilution Publication
361397541:100Mendiola, P.J., et al. 2022. Role of Cholesterol in the Regulation of Hydrogen Sulfide Signaling within the Vascular Endothelium. Antioxidants, 1680.
30484346not listedWang, B., et al. 2019. Furosemide reduces BK-αβ4-mediated K+ secretion in mice on an alkaline high-K+ diet. American Journal of Physiology Renal Physiology, R341-F350.
291449741ug/mlIrie, T., et al. 2017. Double-Nanodomain Coupling of Calcium Channels, Ryanodine Receptors, and BK Channels Controls the Generation of Burst Firing. Neuron, 856-870.
259482591:100Hirono, M., et al. 2015. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.. Journal of Neuroscience, 7082-7094.
22612819not listedMenegola, M., et al. 2012. The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice.. Epilepsia, 142-149.
216764991:300Wykes, R., et al. 2012. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice. . Neurobiology of aging, 1609-1623.
Immunohistochemistry: Rat
PMID Dilution Publication
28865873not listedSimakova, M.N., et al. 2017. Statin therapy exacerbates alcohol-induced constriction of cerebral arteries via modulation of ethanol-induced BK channel inhibition in vascular smooth muscle. Biochemical Pharmacology, 81-93.
259482591:100Hirono, M., et al. 2015. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.. Journal of Neuroscience, 7082-7094.
22675541not listedManning CF, et al. 2012. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance.. PLoS One, e38313.
18668683not listedBuniel, M., et al. 2008. Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body.. Journal of Comparative Neurology, 367-377.
Immunoprecipitation: Human
PMID Dilution Publication
3321724210ugZyrianova, T., et al. 2021. BK Channels Regulate LPS-induced CCL-2 Release from Human Pulmonary Endothelial Cells. American Journal of Repiratory Cell and Molecular Biology, 224-234.
28165042not listedGuan, X., et al. 2017. Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation. Scientific Reports, 42240.
Immunoprecipitation: Mouse
PMID Dilution Publication
25267913not listedMartinez-Espinosa, P.L., et al. 2014. Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity.. The Journal of General Physiology, .
Immunoprecipitation: Rat
PMID Dilution Publication
30181277not listedZhang, J., et al. 2018. Glutamate-activated BK channel complexes formed with NMDA receptors. PNAS, E9006-E9014.
PLA: Human
PMID Dilution Publication
290708991:200Nieves-Cintrón, M., et al. 2017. Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes. Scientific Reports, 14058.
Water Blot: Mouse
PMID Dilution Publication
25267913not listedMartinez-Espinosa, P.L., et al. 2014. Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity.. The Journal of General Physiology, .
Western Blot: Human
PMID Dilution Publication
386044591:200Maliszewska-Olejniczak, K, et al. 2024. Deficiency of the BKCa potassium channel displayed significant implications for the physiology of the human bronchial epithelium. Mitochondrion, 101880.
383838791:1000Li, G, et al. 2024. Targeting Large-Conductance Calcium-Activated Potassium Channels to Ameliorate Lipopolysaccharide-Induced Depressive-Like Behavior in Mice. Neurochemical research, .
37689317not listedGłuchowska, A, et al. 2023. Lack of activity of the mitochondrial large-conductance calcium-regulated potassium channels in senescent vascular smooth muscle cells. Mechanisms of Ageing and Development, 111871.
35104503not listedChen, G., et al. 2022. The leucine-rich repeat domains of BK channel auxiliary γ subunits regulate their expression, trafficking, and channel-modulation functions. The Journal of biological chemistry, 101664.
332172421:200Zyrianova, T., et al. 2021. BK Channels Regulate LPS-induced CCL-2 Release from Human Pulmonary Endothelial Cells. American Journal of Repiratory Cell and Molecular Biology, 224-234.
30639285not listedZanatta, A.P., et al. 2019. New ionic targets of 3,3',5'-triiodothyronine at the plasma membrane of rat Sertoli cells. Biochimica et Biophysica acta Biomembranes, 748-759.
281650421:1000Guan, X., et al. 2017. Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation. Scientific Reports, 42240.
278720491:2000Nishijima, Y., et al. 2017. Contribution of Kv1. 5 channel to hydrogen peroxide–induced human arteriolar dilation and its modulation by coronary artery disease. . Circulation research, 658-669.
275922262ug/mlZhang, J., et al. 2017. The mitochondrial BKCa channel cardiac interactome reveals BKCa association with the mitochondrial import receptor subunit Tom22, and the adenine nucleotide translocator. Mitochondrion, 84-101.
27763639not listedTajhya, R.B., et al. 2016. Functional KCa1.1 channels are crucial for regulating the proliferation, migration and differentiation of human primary skeletal myoblasts. Cell Death and Disease, e2426.
263387061:200Manzanares, D., et al. 2016. Airway Surface Dehydration by Transforming Growth Factor β (TGF-β) in Cystic Fibrosis Is Due to Decreased Function of a Voltage-dependent Potassium Channel and Can Be Rescued by the Drug Pirfenidone.. The Journal of Biological Chemistry, 25710-25716.
Western Blot: Lamb
PMID Dilution Publication
35733986not listedBeñaldo, F.A., et al. 2022. Cinaciguat (BAY-582667) Modifies Cardiopulmonary and Systemic Circulation in Chronically Hypoxic and Pulmonary Hypertensive Neonatal Lambs in the Alto Andino. Frontiers in Physiology, 864010.
Western Blot: Mouse
PMID Dilution Publication
358435301:4000Liu, Y., et al. 2022. Hyperactivity of Purkinje Cell and Motor Deficits in C9orf72 Knockout Mice. Molecular and Cellular Neurosciences, 103756.
33449847not listedLeo, M.D., et al. 2021. TMEM16A channel upregulation in arterial smooth muscle cells produces vasoconstriction during diabetes. American Journal of Physiology Heart and Circulatory Physiology, H1089-H1101.
329769821:4000Liu, Y., et al. 2020. The abnormal firing of Purkinje cells in the knockin mouse model of DYT1 dystonia. Brain Research Bulletin, 14-22.
312966631:1000Yang, X., et al. 2019. Large-conductance calcium-activated potassium channels mediate lipopolysaccharide-induced activation of murine microglia. Journal of Biological Chemistry, 12921-12932.
28416688not listedYang, C., et al. 2017. Knockout of the LRRC26 subunit reveals a primary role of LRRC26-containing BK channels in secretory epithelial cells. PNAS USA, E3739-E3747.
276056261:1000Illison, J., et al. 2016. Obesogenic and Diabetogenic Effects of High-Calorie Nutrition Require Adipocyte BK Channels. Diabetes, 3621-3635.
269407701ug/mlWhitt, J.P., et al. 2016. BK channel inactivation gates daytime excitability in the circadian clock.. Nature Communications, 10837.
26772433not listedSingh, H., et al. 2016. MaxiK channel interactome reveals its interaction with GABA transporter 3 and heat shock protein 60 in the mammalian brain.. Neuroscience, 76-107.
25948259not listedHirono, M., et al. 2015. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.. Journal of Neuroscience, 7082-7094.
Western Blot: Rat
PMID Dilution Publication
302719631:1000Yu, D., et al. 2018. BK channel deacetylation by SIRT1 in dentate gyrus regulates anxiety and response to stress. Communications Biology, 82.
301812771:100Zhang, J., et al. 2018. Glutamate-activated BK channel complexes formed with NMDA receptors. PNAS, E9006-E9014.
290462971:1000West, C.A., et al. 2018. Renal and colonic potassium transporters in the pregnant rat. American Journal of Physiology Renal Physiology, F251-F259.
274407761:10 (supe)Xu, C., et al. 2017. (Pro)Renin receptor regulates potassium homeostasis through a local mechanism. American Journal of Physiology Renal Physiology, F641-F656.
280903001:400Detweiler, N.D., et al. 2016. BK channels in rat and human pulmonary smooth muscle cells are BKα-β1 functional complexes lacking the oxygen-sensitive stress axis regulated exon insert. Pulmonary Circulation, 563-575.
271654301:500Pethő, Z., et al. 2016. Different expression of β subunits of the KCa1.1 channel by invasive and non-invasive human fibroblast-like synoviocytes. Arthritis Research and Therapy, 103.
Western Blot: Sheep
PMID Dilution Publication
31063821not listedHerrera, E.A., et al. 2019. The role of nitric oxide signaling in pulmonary circulation of high- and low-altitude newborn sheep under basal and acute hypoxic conditions. Nitric Oxide, 71-80.
Western Blot: Swine
PMID Dilution Publication
295960161:500Olver, T.D., et al. 2018. Chronic interval exercise training prevents BKCa channel-mediated coronary vascular dysfunction in aortic-banded miniswine. Journal of Applied Physiology, 86-96.
Western Blot: Xenopus
PMID Dilution Publication
277993211:1000Kuntamallappanavar, G., et al. 2016. Alcohol modulation of BK channel gating depends on β subunit composition. Journal of General Physiology, 419-440.
Additional Publications: Unspecified
PMID Publication
29128791López-Dyck, E., et al. 2017. ACPA and JWH-133 modulate the vascular tone of superior mesenteric arteries through cannabinoid receptors, BKCa channels, and nitric oxide dependent mechanisms. Pharmacological Reports, 1131-1139.
28468834Wang, W., et al. 2017. A voltage-dependent K+ channel in the lysosome is required for refilling lysosomal Ca2+ stores. Journal of Cell Biology, 1715-1730.
26301573Pratt, C.P., et al. 2016. Fluorogenic Green-Inside Red-Outside (GIRO) Labeling Approach Reveals Adenylyl Cyclase-Dependent Control of BKα Surface Expression.. Bioconjugate Chemistry, 1963-1971.
26390131Zhang, Y.Y., et al. 2015. Effects of BKCa and Kir2.1 Channels on Cell Cycling Progression and Migration in Human Cardiac c-kit+ Progenitor Cells. PLoS One, e0138581.
26269637Dell'Orco, J.M., et al. 2015. Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability.. Journal of Neuroscience, 11292-11307.
26261328Zhao, G., et al. 2015. STIM1 enhances SR Ca2+ content through binding phospholamban in rat ventricular myocytes.. PNAS USA, E4792-E4801.
26231201Liu, Y., et al. 2015. A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function.. The FASEB Journal, 4829-4839.
26179602Leo, M.D., et al. 2015. Angiotensin II stimulates internalization and degradation of arterial myocyte plasma membrane BK channels to induce vasoconstriction.. American Journal of Physiology-Cell Physiology, C392-C402.
25653344Rohmann, K.N., et al. 2015. Activation of BK and SK channels by efferent synapses on outer hair cells in high-frequency regions of the rodent cochlea. Journal of Neuroscience, 1821-1830.
25607984Cornelius, R.J., et al. 2015. Low Na, high K diet and the role of aldosterone in BK-mediated K excretion.. PLoS One, .
25252152Tanner, M.R., et al. 2015. KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates disease in rat models of rheumatoid arthritis.. Arthritis & Rheumatology, 96-106.
25620932White, R.S., et al. 2014. Evaluation of mouse urinary bladder smooth muscle for diurnal differences in contractile properties.. Frontiers in Pharmacology, 293.
25070892Zhang, Z., et al. 2014. The angiotensin II type 1 receptor (AT1R) closely interacts with large conductance voltage- and Ca2+-activated K+ (BK) channels and inhibits their activity independent of G-protein activation.. The Journal of Biological Chemistry, 25678-25689.
24921651Nourian, Z., et al. 2014. Large conductance Ca2+-activated K+ channel (BKCa) α-subunit splice variants in resistance arteries from rat cerebral and skeletal muscle vasculature.. PLoS One, e98863.
24914944Li, Y., et al. 2014. BK channels regulate myometrial contraction by modulating nuclear translocation of NF-κB.. Endocrinology, 3112-3122.
24705555Hayoz, S., et al. 2014. Aging increases capacitance and spontaneous transient outward current amplitude of smooth muscle cells from murine superior epigastric arteries.. American Journal of Physiology-Heart and Circulatory Physiology, H1512-H1524.
24667981Samengo, I., et al. 2014. Large conductance calcium-activated potassium channels: their expression and modulation of glutamate release from nerve terminals isolated from rat trigeminal caudal nucleus and cerebral cortex.. Neurochemical Research, 901-910.
24570002Yi, F., et al. 2014. Regulation of large conductance Ca2+-activated K+ (BK) channel β1 subunit expression by muscle RING finger protein 1 in diabetic vessels.. The Journal of Biological Chemistry, 10853-10864.
24464482Leo, M.D., et al. 2014. Dynamic regulation of β1 subunit trafficking controls vascular contractility.. PNAS USA, 2361-2366.
24414257Manzanares, D., et al. 2014. IFN-γ-mediated reduction of large-conductance, Ca2+-activated, voltage-dependent K+ (BK) channel activity in airway epithelial cells leads to mucociliary dysfunction. American Journal of Physiology. Lung Cellular and Molecular Physiology, L453-L462.
24333777Lu, R., et al. 2014. BKCa channels expressed in sensory neurons modulate inflammatory pain in mice.. Pain, 556-565.
24137539Mannowetz, N., et al. 2013. Slo1 is the principal potassium channel of human spermatozoa.. Elife, e01009.
23986520van der Lubbe, N., et al. 2013. K+-induced natriuresis is preserved during Na+ depletion and accompanied by inhibition of the Na+-Cl- cotransporter.. American Journal of Physiology. Renal Physiology, F1177-F1188.
23761673Wen, D., et al. 2013. Regulation of BK-α expression in the distal nephron by aldosterone and urine pH. American Journal of Physiology. Renal Physiology, F463-F476.
23282326Maison, S.F., et al. 2013. Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea. Journal of Neurophysiology, 1525-1534.
23255603Li, M., et al. 2013. The β1-subunit of the MaxiK channel associates with the thromboxane A2 receptor and reduces thromboxane A2 functional effects. Journal of Biological Chemistry, 3668-3677.
23174562Montgomery, J.R., et al. 2013. Mis-expression of the BK K(+) channel disrupts suprachiasmatic nucleus circuit rhythmicity and alters clock-controlled behavior. American Journal of Physiology. Cell Physiology, C299-C311.
23112153Montgomery, J.R., et al. 2012. Genetic activation of BK currents in vivo generates bidirectional effects on neuronal excitability.. PNAS USA, 18997-19002.
23064759Zhang, J., et al. 2012. Role of the BK channel (KCa1.1) during activation of electrogenic K+ secretion in guinea pig distal colon. American Journal of Physiology. Gastrointestinal and Liver Physiology, G1322-G1334.
22992678McFerrin, M.B., et al. 2012. Differential role of IK and BK potassium channels as mediators of intrinsic and extrinsic apoptotic cell death.. American Journal of Physiology-Cell Physiology, C1070-C1078.
22767231Föller, M., et al. 2012. AMP-activated protein kinase in BK-channel regulation and protection against hearing loss following acoustic overstimulation.. The FASEB Journal, 4243-4253.
22607137Zhang, X.L., et al. 2012. Inflammation-induced changes in BK(Ca) currents in cutaneous dorsal root ganglion neurons from the adult rat.. Molecular Pain, 37.
22492042Tanimoto, N., et al. 2012. BK channels mediate pathway-specific modulation of visual signals in the in vivo mouse retina.. Journal of Neuroscience, 4861-4866.
22438928Shruti, S., et al. 2012. The brain-specific Beta4 subunit downregulates BK channel cell surface expression.. PLoS One, e33429.
22291145Almassy, J., et al. 2012. Apical Ca2+-activated potassium channels in mouse parotid acinar cells.. The Journal of General Physiology, 121-133.
22158710Zhang, D.X., et al. 2012. H2O2-induced dilation in human coronary arterioles: role of protein kinase G dimerization and large-conductance Ca2+-activated K+ channel activation.. Circulation Research, 471-480.
22074915Hu, X., et al. 2012. KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis.. The Journal of Biological Chemistry, 4014-4022.
21795739Soloff, M.S., et al. 2011. Effects of progesterone treatment on expression of genes involved in uterine quiescence.. Reproductive Sciences, 781-797.
21606111McDermott, C.M., et al. 2011. Activation of κ opioid receptors increases intrinsic excitability of dentate gyrus granule cells.. The Journal of Physiology, 3517-3532.
21325638Li, B.Y., et al. 2011. KCa1.1 channel contributes to cell excitability in unmyelinated but not myelinated rat vagal afferents.. American Journal of Physiology-Cell Physiology, C1393-C1403.
21135099Tajima, N., et al. 2011. Activity of BK(Ca) channel is modulated by membrane cholesterol content and association with Na+/K+-ATPase in human melanoma IGR39 cells.. The Journal of Biological Chemistry, 5624-5638.
21079807Wersinger, E., et al. 2010. BK channels mediate cholinergic inhibition of high frequency cochlear hair cells.. PLoS One, e13836.
21072171Mazar, J., et al. 2010. The regulation of miRNA-211 expression and its role in melanoma cell invasiveness.. PLoS One, e13779.
20959415Li, M., et al. 2010. Thromboxane A2 receptor and MaxiK-channel intimate interaction supports channel trans-inhibition independent of G-protein activation.. PNAS USA, 19096-19101.
20931182Ernest, N.J., et al. 2010. Biophysical properties of human medulloblastoma cells.. The Journal of Membrane Biology, 59-69.
20826678Pyott, S., et al. 2010. Ca(2+) and Ca(2+)-activated K(+) channels that support and modulate transmitter release at the olivocochlear efferent-inner hair cell synapse. Journal of Neuroscience, 12157-12167.
20713546Zhao, G., et al. 2010. Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells.. The Journal of General Physiology, 283-291.
20681950Martire, M., et al. 2010. Pre-synaptic BK channels selectively control glutamate versus GABA release from cortical and hippocampal nerve terminals.. Journal of Neurochemistry, 411-422.
20630939Kim, E.Y., et al. 2010. Regulation of podocyte BK(Ca) channels by synaptopodin, Rho, and actin microfilaments.. American Journal of Physiology. Renal Physiology, F597-F604.
20613726Yan, J., et al. 2010. LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium.. Nature, 513-516.
20595025Kaufmann, W.A., et al. 2010. Two distinct pools of large-conductance calcium-activated potassium channels in the somatic plasma membrane of central principal neurons.. Neuroscience, 974-986.
20576683Holtzclaw, J.D., et al. 2010. Shear stress-induced volume decrease in C11-MDCK cells by BK-alpha/beta4.. Am The Journal of Physiology Renal Physiol., F507-F516.
20566869Chen, X., et al. 2010. Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels.. PNAS USA, 12323-12328.
20299355Holtzclaw, J.D., et al. 2010. Intercalated cell BK-alpha/beta4 channels modulate sodium and potassium handling during potassium adaptation. Journal of American Society of Nephrology, 634-645.
19794150Kim, E.Y., et al. 2009. Neph1 regulates steady-state surface expression of Slo1 Ca(2+)-activated K(+) channels: different effects in embryonic neurons and podocytes.. American Journal of Physiology-Cell Physiology, C1379-C1388.
19731297Schweizer, F.E., et al. 2009. Distribution of high-conductance calcium-activated potassium channels in rat vestibular epithelia.. Journal of Comparative Neurology, 134-145.
19619511Sokolowski, B., et al. 2009. The large-conductance Ca(2+)-activated K(+) channel interacts with the apolipoprotein ApoA1. Biochemical and Biophysical Research Communications, 671-675.
19578543Yang, C.T., et al. 2009. Interactions between beta subunits of the KCNMB family and Slo3: beta4 selectively modulates Slo3 expression and function. PLoS One, e6135.
19458125Grimm, P.R., et al. 2009. Role of BKbeta1 in Na+ reabsorption by cortical collecting ducts of Na+-deprived mice. American Journal of Physiology and Renal Physiology, F420-F428.
19412945Kaufmann, W.A., et al. 2009. Large-conductance calcium-activated potassium channels in purkinje cell plasma membranes are clustered at sites of hypolemmal microdomains. Journal of Comparative Neurology, 215-230.
19403801Ridgway, L.D., et al. 2009. MAGI-1 interacts with Slo1 channel proteins and suppresses Slo1 expression on the cell surface.. American Journal of Physiology-Cell Physiology, C55-C65.
19052171Kim, E.Y., et al. 2009. Canonical transient receptor potential channel (TRPC)3 and TRPC6 associate with large-conductance Ca2+-activated K+ (BKCa) channels: role in BKCa trafficking to the surface of cultured podocytes.. Molecular Pharmacology, 466-477.
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17060504Xu, H., et al. 2006. Activation of potassium channels by tempol in arterial smooth muscle cells from normotensive and deoxycorticosterone acetate-salt hypertensive rats.. Hypertension, 1080-1087.
16903852Sailer, C.A., et al. 2006. Immunolocalization of BK channels in hippocampal pyramidal neurons. European Journal of Neuroscience, 442-454.
16566008Misonou, H., et al. 2006. Immunolocalization of the Ca2+-activated K+ channel Slo1 in axons and nerve terminals of mammalian brain and cultured neurons.. Journal of Comparative Neurology, 289-302.

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