Anti-TARPGamma2/4/8 Antibody (N245/36)

Name: Anti-TARPGamma2/4/8 Antibody
Brand: NeuroMab
SKU: 75-252
Price: 319.0 USD
Availability: InStock

6 Citations

Our Anti-TARPGamma2/4/8 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N245/36. It detects mouse and rat TARPGamma2/4/8, and is purified by Protein A chromatography. It is great for use in ICC, WB.

Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP- tagged TARPGamma2/3/4/8 or untagged Kv2.1 plasmid and probed with N245/36 (left) and N86/8 (right) TC supe.

Adult rat brain membrane immunoblot.

Species Reactivity

Mouse, Rat

Applications

ICC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-252

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

TARPGamma2/4/8

Target Description

Voltage-dependent calcium channel gamma-2 subunit, TARPGamma2 or Stargazin is encoded by the gene CACNG2 and is the transmembrane gamma subunit of the L-type calcium channel. Stargazin is in involved in regulation and trafficking of the ligand gated ion channel AMPA receptors. It is thought to play a role in learning and memory. Diseases associated with this gene include forms of deafness, Mental Retardation and childhood absnce epilepsy.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N245/36

Isotype

IgG2a

Applications

ICC, WB

Host Species

Mouse

Gene Name

Cacng2 Stg Cacng4 Cacng8

Molecular Weight

36 kDa

Antigen

Fusion protein amino acids 203-323 (cytoplasmic C-terminus) of rat TARPGamma2 (accession number Q71RJ2) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_10676103

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Cross-react with TARPGamma4 and TARPGamma8Does not cross-react with TARPGamma3

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Voltage-dependent calcium channel gamma-2 subunit (Neuronal voltage-gated calcium channel gamma-2 subunit) (Stargazin) (Transmembrane AMPAR regulatory protein gamma-2) (TARP gamma-2) Voltage-dependent calcium channel gamma-4 subunit (Neuronal voltage-gated calcium channel gamma-4 subunit) (Transmembrane AMPAR regulatory protein gamma-4) (TARP gamma-4) Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage-gated calcium channel gamma-8 subunit) (Transmembrane AMPAR regulatory protein gamma-8) (TARP gamma-8)

UniProt Details

UniProt (Human): Q9Y698
UniProt (Immunogen Species): Q71RJ2

Product Specific References for Applications and Species

Immunohistochemistry: Mouse
Western Blot: Mouse | Rat

Immunohistochemistry: Mouse
PMID	Dilution	Publication
23354328	1:50	Tao, Y., et al. 2013. Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons.. Nature Neuroscience, 290-299.

Western Blot: Mouse
PMID	Dilution	Publication
31604597	not listed	Schwenk, J., et al. 2019. An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity. Neuron, 680-692.
29199957	1:500	Schmitz, L.J.M., et al. 2017. The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory. eLife, e24192.
23268962	1:200	Nagura, H., et al. 2012. Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice.. Molecular Brain, 43.

Western Blot: Rat
PMID	Dilution	Publication
25242221	not listed	Schwenk, J., et al. 2014. Regional diversity and developmental dynamics of the AMPA-receptor proteome in the mammalian brain.. Neuron, 41-54.
24853943	not listed	Boudkkazi, S., et al. 2014. Cornichon2 dictates the time course of excitatory transmission at individual hippocampal synapses.. Neuron, 848-858.

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Anti-TARPGamma2/4/8 Antibody (N245/36)

SKU: 75-252

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-TARPGamma2/4/8 Antibody

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