Anti-TrpC1 Antibody (1F1)

Name: Anti-TrpC1 Antibody
Brand: NeuroMab
SKU: 75-278
Price: 319.0 USD
Availability: InStock

Our Anti-TrpC1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone 1F1. It is KO validated, detects human, mouse, and rat TrpC1, and is purified by Protein A chromatography. It is great for use in ICC, WB.

Adult rat brain membrane immunoblot

Species Reactivity

Human, Mouse, Rat

Applications

ICC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

Go to Full Product Details

Data Sheet

KO Validated

SKU: 75-278

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

TrpC1

Target Description

Short transient receptor potential channel 1 or TrpC1 is encoded by the gene TRPC1.TrpC1 belongs to the transient receptor family, a group of membrane bound ion channels that have a relatively non-selective permeability to cations, including sodium, calcium and magnesium. TrpC1 expression seems to be ubiquitous, and is widely expressed in throughout the brain.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

1F1

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

TRPC1 TRP1

Molecular Weight

80-90 kDa

Antigen

Fusion protein amino acids 27-306 (cytoplasmic N-terminus) of human TRPC1 (accession number P48995) produced recombinantly in E. Coli.

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2315951

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with TRPC4 (based on KO validation results)

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1)

UniProt Details

UniProt (Human): P48995
UniProt (Immunogen Species): P48995

Product Specific References for Applications and Species

Western Blot: Human | Mouse

Western Blot: Human
PMID	Dilution	Publication
31838437	1:300	Dyrda, A., et al. 2020. STIM1 long and STIM1 gate differently TRPC1 during store-operated calcium entry. Cell Calcium, 102134.
27875305	1:1000	Ludlow, M.J., et al. 2017. (-)-Englerin A-evoked Cytotoxicity Is Mediated by Na+ Influx and Counteracted by Na+/K+-ATPase.. Journal of Biological Chemistry, 723-731.
26133660	not listed	Hong, C., et al. 2015. Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington''s disease.. Brain, 3030-3047.

Western Blot: Mouse
PMID	Dilution	Publication
29920354	1:500	Lee, S.H., et al. 2018. Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice. Journal of Allergy and Clinical Immunology, 1349-1352.

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Anti-TrpC1 Antibody (1F1)

SKU: 75-278

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-TrpC1 Antibody

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