Anti-TrpV1 Antibody (N221/17)
Our Anti-TrpV1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N221/17. It is KO validated, detects human, mouse, and rat TrpV1, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
Immunofluorescence staining of adult dorsal root ganglion sections from TrpV1 WT and -/- mice with N221/17 TC supe (red), Kv1.2 rabbit polyclonal (green) and Hoechst nuclear stain (blue). Images courtesy of Matthew Rasband (Baylor College of Medicine).
Product Specific References for Applications and Species
- Immunocytochemistry: Mouse | Rat
- Immunohistochemistry: Mouse | Rat
- Western Blot: Human | Mouse | Rat
| Immunocytochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 32584793 | not listed | Otto, M., et al. 2020. 12(S)-HETE Mediates Diabetes Induced Endothelial Dysfunction by Activating Intracellular Endothelial Cell TRPV1. Journal of Clinical Investigation, 4999-5010. |
| 28606925 | not listed | Gu, Y., et al. 2017. Polarity of varicosity initiation in central neuron mechanosensation. Journal of Cell Biology, 2179-2199. |
| 25970319 | 5ug/ml | Mickle, A.D., et al. 2015. Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking. Pain , 1620-1636. |
| 22933780 | 5ug/ml | Loo, L., et al. 2012. The C-type natriuretic peptide induces thermal hyperalgesia through a noncanonical Gβγ-dependent modulation of TRPV1 channel.. Journal of Neuroscience, 11942-11955. |
| Immunocytochemistry: Rat | ||
| PMID | Dilution | Publication |
| 26416880 | 1:100 | Cohen, M.R., et al. 2015. Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons.. Molecular and Cellular Biology, 4238-4252. |
| Immunohistochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 36472910 | not listed | He, S., et al. 2022. A Human TRPV1 Genetic Variant Within the Channel Gating Domain Regulates Pain Sensitivity in Rodents. Journal of Clinical Investigation, e163735. |
| 28326944 | 1:400 | Peng, X., et al. 2017. Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms. Molecular Pain, . |
| Immunohistochemistry: Rat | ||
| PMID | Dilution | Publication |
| 35602097 | 1:100 | Wang, Q., et al. 2022. Capsaicin Alleviates Vascular Endothelial Dysfunction and Cardiomyopathy via TRPV1/eNOS Pathway in Diabetic Rats. Oxidative medicine and cellular longevity, 6482363. |
| 25029033 | 1:100 | Iannotti, F.A., et al. 2014. Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability. ACS Chemical Neuroscience, 1131-1141. |
| Western Blot: Human | ||
| PMID | Dilution | Publication |
| 34331901 | not listed | Taylor, D., et al. 2021. Hypothermia promotes mitochondrial elongation In cardiac cells via inhibition of Drp1. Cryobiology, 42-55. |
| 23139219 | not listed | Bouyer, P.G., et al. 2013. Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1.. American Journal of Physiology: GLP, G142-156. |
| Western Blot: Mouse | ||
| PMID | Dilution | Publication |
| 36367592 | not listed | Wu, C., et al. 2022. Spinal Cord Astrocytes Regulate Myocardial Ischemia-Reperfusion Injury. Basic Research In Cardiology, 56. |
| 35726573 | 1:1000 | Cho, A., et al. 2022. Nociceptive Signaling Through Transient Receptor Potential Vanilloid 1 is Regulated by Cyclin Dependent Kinase 5-Mediated Phosphorylation of T407 In Vivo. Molecular Pain, 17448069221111400. |
| 23139219 | not listed | Bouyer, P.G., et al. 2013. Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1.. American Journal of Physiology: GLP, G142-156. |
| Western Blot: Rat | ||
| PMID | Dilution | Publication |
| 36367592 | not listed | Wu, C., et al. 2022. Spinal cord astrocytes regulate myocardial ischemia-reperfusion injury. Basic Research Cardiology, 56. |
| 32557241 | not listed | Yuetao, M., et al. 2020. TRPV1, Targeted by miR-338-3p, Induces Neuropathic Pain by Interacting With NECAB2. Journal of Molecular Neuroscience, 55-65. |
| 26416880 | 1:500 | Cohen, M.R., et al. 2015. Nerve Growth Factor Regulates Transient Receptor Potential Vanilloid 2 via Extracellular Signal-Regulated Kinase Signaling To Enhance Neurite Outgrowth in Developing Neurons.. Molecular and Cellular Biology, 4238-4252. |
| 25014183 | 1:1000 | Ambrosino, P., et al. 2014. Functional and biochemical interaction between PPARα receptors and TRPV1 channels: Potential role in PPARα agonists-mediated analgesia.. Pharmacological Research, 113-122. |
| 24861565 | 1:500 | Navarria, A., et al. 2014. The dual blocker of FAAH/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis.. Pharmacological Research, 151-159. |
| 23139219 | not listed | Bouyer, P.G., et al. 2013. Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1.. American Journal of Physiology: GLP, G142-156. |