Anti-WRN Antibody (N428/12)
Our Anti-WRN mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N428/12. It detects human and rat WRN, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
SKU: 75-423
Ships: 1-2 business days
Product Details
WRN
Werner syndrome ATP-dependent helicase, WRN RecQ Like Helicase or DNA Helicase, RecQ-Like Type 3 is encoded by the gene WRN and is a member of the WRN RecQ Like Helicase family. WRN acts as a DNA helicase that is involved in DNA repair, replication, recombination and maintenance of DNA stability. WRN is a multifunctional enzyme with ATP dependent helicase activity, and is the only RecQ helicase member that has 3’ to 5’ exonuclease activity. WRN is expressed within the central nervous system and brain Diseases associated with this gene include Werner Syndrome and Medulloblastoma.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N428/12
IgG1
ICC, IHC, WB
Mouse
WRN RECQ3 RECQL2
160 kDa
Fusion protein amino acids 38-236 (exonuclease domain) of human WRN (accession number Q14191) produced recombinantly in E. Coli
Human, Rat
AB_2714203
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Unconjugated
No cross-reactivity reported
Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2)