We are excited to announce the release of a new line of recombinant chimeric chicken versions of many of our top selling NeuroMab mouse monoclonal antibodies!
Download our Chimeric Chicken flyer!
A chimeric antibody is a recombinant hybrid antibody that combines domains from different species, such as mice and chickens, to create an antibody with improved functionality.
Advantages of Our Chimeric Chicken Antibodies
- Reproducibility: Because they are recombinant, chimeric chicken antibodies offer a consistent and reproducible source of antibody.
- Animal-friendly: Our chicken chimerics are produced in cultured mammalian cells using serum-free and protein-free growth medium. No animals are used in their production.
- Known binding properties: The mouse variable regions – which contain the antigen binding sites are from well-characterized and highly validated NeuroMab antibodies.
- Reduced background: Using mouse antibodies on mouse samples can be problematic if the mouse secondary antibodies react with endogenous mouse IgG. Chicken chimerics use an anti-chicken secondary, greatly reducing background signal.
- Easier multiplexing: The use of a unique species such as chicken allows researchers to perform a triplex immunofluorescence experiment alongside the standard mouse and rabbit primaries without worrying about the cross reactivity of another mammalian antibody
Chimeric Chicken Antibodies Launching Soon:
| Fall 2024 | Winter 2024 | Winter 2025 | Spring 2025 |
| Anti-TMEM119 | Anti-PSD95 MAGUK | Anti-GFP (IgG2a) | Anti-GluA1/GluR1 |
| Anti-GFAP | Anti-VGlut1 | Anti-c-Fos | Anti-GluA2/GluR2 |
| Anti-Aldh1L1 | Anti-VGlut2 | Anti-Arl13b | Anti-GluN2B/NR2B |
| Anti-CALB1/calbindin | Anti-GAD65/67 | Anti-B4 Spectrin | Anti-NR2A |
| Anti-Parvalbumin | Anti-VGAT | Anti-LRRK2/Dardarin (IgG2a) | Anti-NR1 |
| Anti-CALB2 | Anti-Bassoon | Anti-Nav1.1 Na+ Channel | Anti-NR2B |
| Anti-Homer1 | Anti-Ankyrin G | Anti-RGS14 | |
| Anti-Olig1 | |||
| Anti-VAChT |
What are chimeric antibodies?
A chimeric antibody is a recombinant hybrid antibody that combines domains from different species, such as mice and chickens, to create an antibody with improved functionality. On the immunoglobulin molecule, either the Fc region or the entire constant region of a mouse mAb may be replaced with that of a chicken (or other species) antibody, while the variable regions remain the same.
Creation of a chimeric chicken antibody by combining mouse IgG variable domains with chicken IgY constant domains:
Keep an eye out for our email updates to be the first to know when we release new chimeric products!