Anti-Potassium Channel, Voltage Gated, Kv2.2 Subunit Antibody

Name: Anti-Potassium Channel, Voltage Gated, Kv2.2 Subunit Antibody
Brand: PhosphoSolutions
SKU: 1002-KV22
Price: 430.0 USD
Availability: InStock

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Our Anti-Potassium Channel, Voltage Gated, Kv2.2 Subunit rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects rat Potassium Channel, Voltage Gated, Kv2.2 Subunit and is antigen affinity purified from pooled serum. It is great for use in WB, IHC.

This antibody was custom made for a university researcher. We do not have access to the appropriate lysate for in-house validation, but it has been validated in publications. Please see references in the description box for further details. If you have aWestern blot or IHC image you'd be willing to share for use on our datasheet and website, please contact us. We offer a free antibody in exchange for your credited image.

Species Reactivity

Rat

Applications

IHC, WB

Host Species

Rabbit

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Data Sheet

Trial Size

Pooled Serum

SKU: 1002-KV22

Volume: 100 µL

Variant

Price:

$430.00

Quantity:

Product Details

Target

Potassium Channel, Voltage Gated, Kv2.2 Subunit

Target Description

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. The delayed rectifier-type (IK)channels (Kv1.5, Kv2.1, and Kv2.2) are expressed on all neuronal somata and proximal dendrites and are also found in a wide variety of non-neuronal cells types including pancreatic islets, alveolar cells and cardiac myocytes (Hwang et al., 1993; Yan et al., 2004; Michaelevski et al., 2003). Kv2.1 and Kv2.2 form distinct populations of K+ channels and these subunits are thought to be primarily responsible for IK in superior cervical ganglion cells (Blaine and Ribera, 1998; Burger and Ribera, 1996).

Format

Antigen Affinity Purified from Pooled Serum

Clonality

Polyclonal

Isotype

IgG

Applications

IHC, WB

Host Species

Rabbit

Gene Name

KCNB2

Molecular Weight

125 kDa

Antigen

Synthetic peptide from the subunit region of the voltage gated potassium channel from the rat and Xenopus Kv2.2 sequence, conjugated to keyhole limpet hemocyanin (KLH).

Species Reactivity

Rat

Antibody Registry ID

AB_2492211

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Prepared from pooled rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Dilution Ranges

WB: 1:1000
IHC: 1:100-1:1000

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~125 kDa voltage gated potassium channel, Kv2.2 subunit.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

delayed rectifier potassium channel protein antibody, KCNB2 antibody, KCNB2_HUMAN antibody, potassium channel Kv2.2 antibody, potassium voltage gated channel subfamily B member 2 antibody, Potassium voltage-gated channel subfamily B member 2 antibody, Voltage-gated potassium channel subunit Kv2.2 antibody

UniProt Details

UniProt (Immunogen Species): Q63099

NCBI Gene ID

621349

Product Specific References for Applications and Species

Immunohistochemistry: Rat | Xenopus
Western Blot: Xenopus

Immunohistochemistry: Rat
PMID	Dilution	Publication
17379638	1:100-1:1000	Guan, D., et al. 2007. Kv2 subunits underlie slowly inactivating potassium current in rat neocortical pyramidal neurons. The Journal of Physiology, 581(3), pp.941-960.

Immunohistochemistry: Xenopus
PMID	Dilution	Publication
18680201	1:100	Gravagna, N.G., et al. 2008. Localization of Kv2. 2 protein in Xenopus laevis embryos and tadpoles. Journal of Comparative Neurology, 510(5), pp.508-524.

Western Blot: Xenopus
PMID	Dilution	Publication
18680201	1:100	Gravagna, N.G., et al. 2008. Localization of Kv2. 2 protein in Xenopus laevis embryos and tadpoles. Journal of Comparative Neurology, 510(5), pp.508-524.

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Product Specific Protocols

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Anti-Potassium Channel, Voltage Gated, Kv2.2 Subunit Antibody

SKU: 1002-KV22

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-Potassium Channel, Voltage Gated, Kv2.2 Subunit Antibody

Product Specific Protocols

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