Anti-WAVE1/SCAR Antibody (K91/36)

15 Citations

Our Anti-WAVE1/SCAR mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K91/36. It is KO validated, detects human, mouse, and rat WAVE1/SCAR, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] and probed with K91/36 (left) or N52A/42 (right) TC supe.
Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] and probed with K91/36 (left) or N52A/42 (right) TC supe.
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Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] and probed with K91/36 (left) or N52A/42 (right) TC supe.
Adult rat brain membrane immunoblot.
Adult rat hippocampus immunohistochemistry.
Adult rat whole brain immunohistochemistry.

Human, Mouse, Rat
ICC, IHC, IP, WB
Mouse
490
550
594
650
Carrier-Free

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Data Sheet
KO Validated KO Validated

SKU: 75-048

Volume: 100 µL
Price:
$329.00
Ships: 1-2 business days

Product Details

WAVE1/SCAR
Wiskott-Aldrich syndrome protein family member 1, Verprolin Homology Domain-Containing Protein 1, Protein WAVE-1 or SCAR1 is encoded by the gene WASF1 and is a member of the Wiskott-Aldrich syndrome protein (WASP)-family. WAVE1/SCAR is an effector protein which transmits of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. WAVE1/SCAR acts as part of the WAVE complex which is involved in the regulation of actin filament reorganization and membrane ruffling. WAVE1/SCAR is expressed in many tissues including brain, ovary, colon, kidney, pancreas and thymus. Diseases associated with this gene include Wiskott-Aldrich Syndrome and Alacrima, Achalasia, And Mental Retardation Syndrome.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
K91/36
IgG1
ICC, IHC, IP, WB
Mouse
WASF1 KIAA0269 SCAR1 WAVE1
75 kDa
Synthetic peptide amino acids 477-498 of human Wave1/Wasp family 1(CQVIPASEPKRHPSTLPVISDAR; accession number Q92558)
Human, Mouse, Rat
AB_2216976
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4
WB: 1:1000
Unconjugated
No cross-reactivity reported
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
Wiskott-Aldrich syndrome protein family member 1 (WASP family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1)
Q92558

Product Specific References for Applications and Species

Immunocytochemistry: Mouse
PMID Dilution Publication
26843638not listedHsiao, K., et al. 2016. Cyfip1 Regulates Presynaptic Activity during Development.. Journal of Neuroscience, 1564-1576.
24153177not listedHan, K., et al. 2013. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.. Nature, 72-77.
Immunocytochemistry: Rat
PMID Dilution Publication
25293574not listedChazeau, A., et al. 2014. Nanoscale segregation of actin nucleation and elongation factors determines dendritic spine protrusion.. The EMBO Journal, 2745-2764.
Western Blot: Human
PMID Dilution Publication
196687091:1000Khodosevich, K., et al. 2009. Major signaling pathways in migrating neuroblasts.. Frontiers in Molecular Neuroscience, 7.
Western Blot: Mouse
PMID Dilution Publication
389816221:1000Zhang, Y., et al. 2024. Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2α phosphorylation via protein interactors and actin cytoskeleton. Human Molecular Genetics, .
36251395not listedKang, M., et al. 2022. CYFIP2 p.Arg87Cys Causes Neurological Defects and Degradation of CYFIP2. Annals of Neurology, .
33613257not listedSahasrabudhe, A., et al. 2021. Cyfip1 Regulates SynGAP1 at Hippocampal Synapses. Frontier in Synaptic Neuroscience, 581714.
331922971:1000Zhang, Y., et al. 2020. Enhanced prefrontal neuronal activity and social dominance behavior in postnatal forebrain excitatory neuron-specific Cyfip2 knock-out mice. . Frontiers in molecular neuroscience, p.201., 574947.
32562430not listedLee, S.H., et al. 2020. Haploinsufficiency of Cyfip2 Causes Lithium-Responsive Prefrontal Dysfunction. Annals of Neurology, 526-543.
303520641:1000-1:2000Chen, Y., et al. 2018. Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice. PLoS One, .
28701918not listedLee, Y., et al. 2017. Striatal transcriptome and interactome analysis of Shank3-overexpressing mice reveals the connectivity between Shank3 and mTORC1 signaling..  Frontiers in Molecular Neuroscience, 10, p.201., 201.
28469556not listedLee, Y., et al. 2017. Integrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations. Frontiers in Molecular Neuroscience, 110.
24439377not listedChia, P.H., et al. 2014. Local F-actin network links synapse formation and axon branching.. Cell, 208-220.
24439376not listedChen, B., et al. 2014. The WAVE regulatory complex links diverse receptors to the actin cytoskeleton. Cell, 195-207.
17301160not listedCheng, A., et al. 2007. Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death.. Journal of Neuroscience, 1519-1528.

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