Anti-Kv4.3 K+ Channel Antibody (K75/41)

Our Anti-Kv4.3 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K75/41. It is KO validated, detects drosophila, guinea pig, human, mouse, and rat Kv4.3 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.



SKU: 75-017

Volume: 100 µL
1-2 business days
Price:
Sale price$374.00

Product Specific References for Applications and Species

Array Tomography: Rat
PMID Dilution Publication
264009491:600Simkin, D., et al. 2015. Aging-related hyperexcitability in CA3 pyramidal neurons is mediated by enhanced A-type K+ channel function and expression. . Journal of Neuroscience, 13206-13218.
Histoblotting: Mouse
PMID Dilution Publication
30634540not listedAlfaro-Ruíz, R., et al. 2019. Expression, cellular and subcellular localisation of Kv4. 2 and Kv4. 3 channels in the rodent hippocampus. . International journal of molecular sciences, 246.
Immunocytochemistry: Human
PMID Dilution Publication
360977911:400Chiu, C.Y., et al. 2022. K+ Channel Kv4.1 is Expressed in the Nociceptors/Secondary Nociceptive Neurons and Participates in Pain Regulation. European Journal of Pain, 2238-2256.
30588629not listedTyan, L., et al. 2019. Long QT syndrome caveolin‐3 mutations differentially modulate Kv4 and Cav1. 2 channels to contribute to action potential prolongation. . The Journal of physiology, 1531-1551.
233240561:5 (supe)David, J.P., et al. 2013. Trafficking of the IKs -complex in MDCK cells: site of subunit assembly and determinants of polarized localization.. Traffic, 399-411.
Immunocytochemistry: Mouse
PMID Dilution Publication
31064843not listedLubbers, E.R., et al. 2019. Defining new mechanistic roles for αii spectrin in cardiac function. . Journal of Biological Chemistry, 9576-9591.
298021971:10 (supe)Cheng, L., et al. 2018. Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration. . Journal of Biological Chemistry, 11022-11032.
298021971:10 (supe)Cheng, L., et al. 2018. Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration. . Journal of Biological Chemistry, 11022-11032.
261967371:100Liu, J., et al. 2015. Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.. PLoS One, e0133274.
215079521:10 (supe)Cheng, L., et al. 2011. Cortactin is required for N-cadherin regulation of Kv1.5 channel function.. The Journal of Biological Chemistry, 20478-20489.
Immunocytochemistry: Rat
PMID Dilution Publication
262392001:8000Cheng, C.F., et al. 2016. Coexpression of auxiliary subunits KChIP and DPPL in potassium channel Kv4-positive nociceptors and pain-modulating spinal interneurons.. Journal of Comparative Neurology, 846-73.
260169051:200You, T., et al. 2015. Two novel Brugada syndrome-associated mutations increase KV4.3 membrane expression and function.. International Journal of Molecular Medicine, 309-315.
Immunohistochemistry: Mouse
PMID Dilution Publication
389422631:1000Esaki, H, et al. 2024. Role of medial prefrontal cortex voltage-dependent potassium 4.3 channels in nicotine-induced enhancement of object recognition memory in male mice. European journal of pharmacology, 176790.
366409131:500Otuyemi, B., et al. 2023. Domain and Cell Type-specific Immunolocalisation of Voltage-gated Potassium Channels in the Mouse Striatum. Journal of Chemical Neuroanatomy, 102233.
360977911:400Chiu, C.Y., et al. 2022. K+ Channel Kv4.1 is Expressed in the Nociceptors/Secondary Nociceptive Neurons and Participates in Pain Regulation. European Journal of Pain, 2238-2256.
350989241:1500Hobson, B.D., et al. 2022. Subcellular proteomics of dopamine neurons in the mouse brain. eLife, e70921.
312487281:250Zheng, Y., et al. 2019. Deep sequencing of somatosensory neurons reveals molecular determinants of intrinsic physiological properties. . Neuron, 598-616.
312487281:250Zheng, Y., et al. 2019. Deep sequencing of somatosensory neurons reveals molecular determinants of intrinsic physiological properties. . Neuron, 598-616.
30634540not listedAlfaro-Ruíz, R., et al. 2019. Expression, cellular and subcellular localisation of Kv4. 2 and Kv4. 3 channels in the rodent hippocampus. . International journal of molecular sciences, 246.
22612819not listedMenegola, M., et al. 2012. The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice.. Epilepsia, 142-149.
216764990.25Wykes, R., et al. 2012. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice. . Neurobiology of aging, 1609-1623.
213297411:500Prüss, H., et al. 2011. Potassium channel expression in adult murine neural progenitor cells.. Neuroscience, 19-29.
171220531:1000Burkhalter, A., et al. 2006. Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses.. Journal of Neuroscience, 12274-82.
17122038not listedMenegola, M., et al. 2006. Unanticipated region- and cell-specific downregulation of individual KChIP auxiliary subunit isotypes in Kv4.2 knock-out mouse brain.. Journal of Neuroscience, 2137-42.
Immunohistochemistry: Rat
PMID Dilution Publication
361819631:400Chiu, C.Y., et al. 2022. NS5806 Inhibits ERK Activation to Attenuate Pain Induced by Peripheral Nerve Injury. Neuroscience Letters, 136890.
32899153not listedAlfaro-Ruíz, R., et al. 2020. Cellular and subcellular localisation of kv4-associated kchip proteins in the rat cerebellum. . International journal of molecular sciences, 6403.
32726631not listedHolderith, N., et al. 2020. A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses. Cell Reports, 107968.
324908111:500Oláh, V.J., et al. 2020. Functional specification of CCK+ interneurons by alternative isoforms of Kv4. 3 auxiliary subunits. . Elife, e58515.
283308771:4000Kuo, Y., et al. 2017. K + Channel Modulatory Subunits KChIP and DPP Participate in Kv4-Mediated Mechanical Pain Control. Journal of Neuroscience, 4391-4404.
278071631:500Rizwan, A.P., et al. 2016. Long-Term potentiation at the mossy fiber–granule cell relay invokes postsynaptic second-messenger regulation of Kv4 channels..  Journal of Neuroscience, 11196-11207.
262392001:4000Cheng, C.F., et al. 2016. Coexpression of auxiliary subunits KChIP and DPPL in potassium channel Kv4-positive nociceptors and pain-modulating spinal interneurons.. Journal of Comparative Neurology, 846-73.
264009491:500Simkin, D., et al. 2015. Aging-related hyperexcitability in CA3 pyramidal neurons is mediated by enhanced A-type K+ channel function and expression. . Journal of Neuroscience, 13206-13218.
253556921:100-1:1000Wang, W.C., et al. 2015. Immunohistochemical localization of DPP10 in rat brain supports the existence of a Kv4/KChIP/DPPL ternary complex in neurons.. Journal of Comparative Neurology, 608-628.
24037673not listedRainnie, D.G., et al. 2014. Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.. Journal of Comparative Neurology, 609-25.
228201701:200Matsuyoshi, H., et al. 2012. Distinct cellular distributions of Kv4 pore-forming and auxiliary subunits in rat dorsal root ganglion neurons.. Life Sciences, 258-263.
224734241:100Huang, C.Y., et al. 2012. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain.. Journal of Comparative Neurology, 3650-3672.
21451062not listedGuan, D., et al. 2011. Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons.. Journal of Neurophysiology, 2976-88.
211294481:1000Bourdeau, M.L., et al. 2011. KChIP1 modulation of Kv4.3-mediated A-type K(+) currents and repetitive firing in hippocampal interneurons.. Neuroscience, 173-87.
208499291:1000Dabrowska, J., et al. 2010. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala.. Neuroscience, 721-33.
18727953not listedMonaghan, M.M., et al. 2008. Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy.. Neuroscience, 550-562.
184953611:500Menegola, M., et al. 2008. Dendritic A-type potassium channel subunit expression in CA1 hippocampal interneurons.. Neuroscience, 953-64.
18495361not listedMenegola, M., et al. 2008. Dendritic A-type potassium channel subunit expression in CA1 hippocampal interneurons.. Neuroscience, 953-64.
165250471:500Kollo, M., et al. 2006. Novel subcellular distribution pattern of A-type K+ channels on neuronal surface. Journal of Neuroscience, 2684-91.
Immunoprecipitation: Human
PMID Dilution Publication
221985080.8 ugZhang, Y.H., et al. 2012. Modulation of human cardiac transient outward potassium current by EGFR tyrosine kinase and Src-family kinases.. Cardiovascular Research, 424-433.
Immunoprecipitation: Mouse
PMID Dilution Publication
3889107612ugBelghazi, M, et al. 2024. High-Resolution Proteomics Unravel a Native Functional Complex of Cav1.3, SK3, and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Midbrain Dopaminergic Neurons. Cells, .
310648432ugLubbers, E.R., et al. 2019. Defining new mechanistic roles for αii spectrin in cardiac function. . Journal of Biological Chemistry, 9576-9591.
Western Blot: Drosophila
PMID Dilution Publication
349325771:500Vallejos, M.J., et al. 2021. Age-related changes in Kv4/Shal and Kv1/Shaker expression in Drosophila and a role for reactive oxygen species. PloS One, e0261087.
Western Blot: Guinea Pig
PMID Dilution Publication
267644821:500Nassal, D.M., et al. 2016. Myocardial KChIP2 expression in guinea pig resolves an expanded electrophysiologic role. . PloS one, e0146561.
Western Blot: Human
PMID Dilution Publication
310740161:1000Wang, Y., et al. 2019. Contribution of potassium channels to action potential repolarization of human embryonic stem cell‐derived cardiomyocytes. . British Journal of Pharmacology, 2780-2794.
258546341:1000Duarri, A., et al. 2015. Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant manner.. Cell Mol Life Sciences, 3387-3399.
22160437not listedMarshall, G.E., et al. 2011. Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade.. Pflügers Archiv: European Journal of Physiology, 537-548.
Western Blot: Mouse
PMID Dilution Publication
36842733not listedMarkandeya, Y.S., et al. 2023. Caveolin-3 and Caveolae Regulate Ventricular Repolarization. Journal of Molecular and Cellular Cardiology, 38-49.
32822706not listedTiwari, D., et al. 2020. The potassium channel Kv4. 2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice.. Experimental Neurology, 113437.
31064843not listedLubbers, E.R., et al. 2019. Defining new mechanistic roles for αii spectrin in cardiac function. . Journal of Biological Chemistry, 9576-9591.
27023865not listedSchilling, J.M., et al. 2016. Electrophysiology and metabolism of caveolin-3-overexpressing mice. . Basic research in cardiology, 1-13.
27023865not listedSchilling, J.M., et al. 2016. Electrophysiology and metabolism of caveolin-3-overexpressing mice. . Basic research in cardiology, 1-13.
26611208not listedZhang, X., et al. 2016. Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias.. Basic Research in Cardiology, 1-13.
243756411:200Lopez-Izquierdo, A., et al. 2014. The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization.. American Journal of Physiology-Heart and Circulatory Physiology, H747-H754.
219436061:1000Sun, W., et al. 2011. DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons.. Neuron, 1102-15.
21646717not listedStein, A.B., et al. 2011. Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes.. Journal of Clinical Investigation, 2641-2650.
21507952not listedCheng, L., et al. 2011. Cortactin is required for N-cadherin regulation of Kv1.5 channel function.. The Journal of Biological Chemistry, 20478-20489.
20943905not listedNorris, A.J., et al. 2010. Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons.. Journal of Neuroscience, 13644-13655.
18045613not listedNiwa, N., et al. 2008. Kv4.3 is not required for the generation of functional Ito,f channels in adult mouse ventricles.. Journal of Molecular and Cellular Cardiology, 95-104.
Western Blot: Rabbit
PMID Dilution Publication
22160437not listedMarshall, G.E., et al. 2011. Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade.. Pflügers Archiv: European Journal of Physiology, 537-548.
Western Blot: Rat
PMID Dilution Publication
29881800not listedLai, Y.C., et al. 2018. Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy. . Epilepsia open, 213-223.
286776791:100Sakai, A., et al. 2017. MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain. . Nature communications, 1-13.
282637091:500Nassal, D.M., et al. 2017. KChIP2 is a core transcriptional regulator of cardiac excitability.. Elife, 17304.
272590671:1000Lei, Z., et al. 2016. Reduced expression of IA channels is associated with post-ischemic seizures.. Epilepsy Research, 40-48.
264009491 : 1000Simkin, D., et al. 2015. Aging-related hyperexcitability in CA3 pyramidal neurons is mediated by enhanced A-type K+ channel function and expression. . Journal of Neuroscience, 13206-13218.
230660171:2000Yao, J.J., et al. 2012. Neuritin activates insulin receptor pathway to up-regulate Kv4.2-mediated transient outward K+ current in rat cerebellar granule neurons.. The Journal of Biological Chemistry, 41534-41545.
230660171:2000Yao, J.J., et al. 2012. Neuritin activates insulin receptor pathway to up-regulate Kv4.2-mediated transient outward K+ current in rat cerebellar granule neurons.. The Journal of Biological Chemistry, 41534-41545.
22180649not listedZhang, M., et al. 2012. KCNE2 protein is more abundant in ventricles than in atria and can accelerate hERG protein degradation in a phosphorylation-dependent manner.. American Journal of Physiology-Heart and Circulatory Physiology, H910-H922.
22160437not listedMarshall, G.E., et al. 2011. Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade.. Pflügers Archiv: European Journal of Physiology, 537-548.
208499291:1000Dabrowska, J., et al. 2010. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala.. Neuroscience, 721-33.
19372218not listedJiang, M., et al. 2009. Dynamic partnership between KCNQ1 and KCNE1 and influence on cardiac IKs current amplitude by KCNE2.. The Journal of Biological Chemistry, 16452-16462.
18458082not listedSchwenk, J., et al. 2008. NMR analysis of KChIP4a reveals structural basis for control of surface expression of Kv4 channel complexes.. The Journal of Biological Chemistry, 18937-18946.
Additional Publications: Unspecified
PMID Publication
26121254Cheng, C.F., et al. 2015. Nerve growth factor-induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain.. Pain, 2295-2309.
25447080Gillet, L., et al. 2015. Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current. Heart Rhythm, 181-192.
25043828Lei, Z., et al. 2014. Reduced expression of IA channels is associated with postischemic seizures in hyperglycemic rats.. Journal of Neuroscience Research, 1775-1784.
24723263Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-999.
23963749Duarri, A., et al. 2013. The L450F [Corrected] mutation in KCND3 brings spinocerebellar ataxia and Brugada syndrome closer together.. NeuroGenetics, 257-258.
23280838Duarri, A., et al. 2012. Mutations in potassium channel kcnd3 cause spinocerebellar ataxia type 19.. Annals of Neurology, 870-880.
22155597Hu, D., et al. 2012. A novel rare variant in SCN1Bb linked to Brugada syndrome and SIDS by combined modulation of Nav1. 5 and Kv4. 3 channel currents. . Heart Rhythm, 760-769.
21895522Lei, Z., et al. 2012. Alterations of A-type potassium channels in hippocampal neurons after traumatic brain injury.. Journal of Neurotrauma, 235-245.
22220205Sethi, J., et al. 2011. Kv4.2 mediates histamine modulation of preoptic neuron activity and body temperature.. PLoS One, e29134.
21849540Hourez, R., et al. 2011. Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1.. Journal of Neuroscience, 11795-11807.
21507952Cheng, L., et al. 2011. Cortactin is required for N-cadherin regulation of Kv1.5 channel function.. The Journal of Biological Chemistry, 20478-20489.
21440618Nowak, A., et al. 2011. Kv3.1b and Kv3.3 channel subunit expression in murine spinal dorsal horn GABAergic interneurones.. Journal of Chemical Neuroanatomy, 30-38.
21115483Schwetz, T.A., et al. 2011. Sialic acids attached to O-glycans modulate voltage-gated potassium channel gating.. The Journal of Biological Chemistry, 4123-4132.
20650612Bealer, S.L., et al. 2010. Autonomic and cellular mechanisms mediating detrimental cardiac effects of status epilepticus.. Epilepsy Research, 66-73.
20371829Norris, A.J., et al. 2010. Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits.. Journal of Neuroscience, 5092-5101.
20354865Cotella, D., et al. 2010. Impaired glycosylation blocks DPP10 cell surface expression and alters the electrophysiology of Ito channel complex.. Pflügers Archiv: European Journal of Physiology, 87-97.
19668710Phuket, T.R., et al. 2009. Kv4 Channels Underlie the Subthreshold-Operating A-type K-current in Nociceptive Dorsal Root Ganglion Neurons.. Frontiers in Molecular Neuroscience, 3.
19344330Eyre, M.D., et al. 2009. Molecular diversity of deep short-axon cells of the rat main olfactory bulb.. European Journal of Neuroscience, 1397-1407.
18978958Clark, B.D., et al. 2008. DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein.. Frontiers in Molecular Neuroscience, 8.
18276729Amarillo, Y., et al. 2008. Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons.. The Journal of Physiology, 2093-2106.
17855600Chien, L.Y., et al. 2007. Reduced expression of A-type potassium channels in primary sensory neurons induces mechanical hypersensitivity.. Journal of Neuroscience, 9855-9865.
17314290Bourdeau, M.L., et al. 2007. Kv4.3-mediated A-type K+ currents underlie rhythmic activity in hippocampal interneurons.. Journal of Neuroscience, 1942-1953.

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