Our Anti-Cavbeta1 Ca2+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N7/18. It detects human, mouse, non-human primate, and rat Cavbeta1 Ca2+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.
Voltage-dependent L-type calcium channel subunit beta-1 or Cav ß1 is encoded by the gene CACNB1. Cavß1 is a cytoplasmic subunit of L type voltage-sensitive calcium channels. These channels facilitate entry of calcium ions into excitable cells are involved in a variety of calcium dependent processes, including neurotransmitter release, muscle contraction, and gene expression. Cavß1 serves to regulate the activity of L-type calcium channels. Cavß1 expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Diseases associated with CACNB1 include Malignant Hyperthermia and epileptic encephalopathy.
Purified by Protein A chromatography
0.5 mg/mL
Monoclonal
N7/18
IgG2a
ICC, IHC
Mouse
CACNB1 CACNLB1
80, 55 kDa
Synthetic peptide amino acids 19-34 of rat Cav1 (PMEVFDPSPQGKYSKR; accession number NP_059042)
Human, Mouse, Non-Human Primate, Rat
AB_2939229
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL550 Ex: 550 nm, Em: 575 nm
Does not cross-react with Cavβ2, Cavβ3, Cavβ4
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
