Anti-GABA-A-R, Beta1 Antibody FL490 Conjugate (N96/55)

Name: Anti-GABA-A-R, Beta1 Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-137-FL490
Price: 460.0 USD
Availability: InStock

Our Anti-GABA(A)R, Beta1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N96/55. It detects human and mouse GABA(A)R, Beta1, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

550

594

650

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Data Sheet

SKU: 75-137-FL490

Volume: 200 µL

Variant

Price:

$460.00

Quantity:

Product Details

Target

GABA(A)R, Beta1

Target Description

Gamma-aminobutyric acid receptor subunit beta-1 or -GABA AR-Beta1 is encoded by the gene GABRB1 GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR alpha 5 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR-Beta1 is primarily expressed in brain at the cell junction, synapse,and the postsynaptic cell membrane. Diseases associated with GABRB1 include early infantile epileptic encephalopathy 43, neurotic disorder, schizophrenia and autism.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N96/55

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Gabrb1

Molecular Weight

55 kDa

Antigen

Fusion protein amino acids 327-450 of mouse GABA-A-R-Beta1 (accession number P50571) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939508

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity against GABA-A-R-Beta2 or -Beta3

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1)

UniProt Details

UniProt (Human): P18505
UniProt (Immunogen Species): P50571

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Anti-GABA-A-R, Beta1 Antibody FL490 Conjugate (N96/55)

SKU: 75-137-FL490

Product Details

Bulk Order Anti-GABA-A-R, Beta1 Antibody FL490 Conjugate

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