Anti-GABA-A-R, Beta3 Antibody FL490 Conjugate (N87/25)

Name: Anti-GABA-A-R, Beta3 Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-149-FL490
Price: 460.0 USD
Availability: InStock

Our Anti-GABA(A)R, Beta3 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N87/25. It detects human and mouse GABA(A)R, Beta3, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

550

594

650

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Data Sheet

SKU: 75-149-FL490

Volume: 200 µL

Variant

Price:

$460.00

Quantity:

Product Details

Target

GABA(A)R, Beta3

Target Description

Gamma-aminobutyric acid receptor subunit beta-3 or GABA AR-Beta3 is encoded by the gene GABRB3. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR-beta3 a is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR beta3 has been found to be expressed in retina, heart and primarily in brain at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane. This gene may be associated with the pathogenesis of several disorders including epilepsy and autism, childhood absence epilepsy 5 and early infantile epileptic encephalopathy 43.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N87/25

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Gabrb3 Gabrb-3

Molecular Weight

55 kDa

Antigen

Fusion protein amino acids 370-433 of mouse GABA-A-R-Beta3 (accession number AAB60502) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2939552

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity against GABA-A-R-Beta1 or –Beta2

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Gamma-aminobutyric acid receptor subunit beta-3 (GABA(A) receptor subunit beta-3)

UniProt Details

UniProt (Human): P28472
UniProt (Immunogen Species): P63080

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Anti-GABA-A-R, Beta3 Antibody FL490 Conjugate (N87/25)

SKU: 75-149-FL490

Product Details

Bulk Order Anti-GABA-A-R, Beta3 Antibody FL490 Conjugate

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