Our Anti-Kvbeta1.2 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K47/42. It is KO validated, detects human, mouse, and rat Kvbeta1.2 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.
Voltage-gated potassium channel subunit beta-1 or Kvβ1.1 is encoded by the gene KCNAB1. Kvß1.1 is a member of the potassium channel, voltage-gated, shaker-related subfamily. Alternative splicing of KCNAB1 allows for three distinct proteins to be made, Kvß1.1, Kvß1.2, and Kvß1.3. Each of these has a unique N terminus. Kvβ1.1 is a cytoplasmic subunit that modulates the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on the channel members. Kvß1 is predominantly expressed in brain and found in hippocampus, cerebral cortex, caudate putamen, colliculus and cerebellum. Diseases associated with this gene include Episodic Ataxia, Type 1 and Familial Temporal Lobe Epilepsy, 3
Purified by Protein A chromatography
0.5 mg/mL
Monoclonal
K47/42
IgG1
ICC, IHC
Mouse
KCNAB1 KCNA1B
65 kDa
Synthetic peptide amino acids 9-28 (ADIPSPKLGLPKSSESALKC, unique Nterminus) of human Kv1.2 (accession number NP_003462)
Human, Mouse, Rat
AB_2939136
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL490 Ex: 491 nm, Em: 515 nm
No cross-reactivity reported
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
