Anti-Nav1.4 Sodium Channel Antibody (N255/38)

Name: Anti-Nav1.4 Sodium Channel Antibody
Brand: NeuroMab
SKU: 75-424
Price: 319.0 USD
Availability: InStock

2 Citations

Our Anti-Nav1.4 sodium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N255/38. It detects rat Nav1.4 sodium channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Immunolabeling of mouse skeletal muscle staining NaV 1.4 (Cat 75-424, 1:1000, red) and acetylcholine receptor (red). The frozen tissue section was fixed with 4% PFA for 10 minutes and mounted before staining. Image kindly provided by Chengjie Xie and Lauren Fish, Brown University.

Species Reactivity

Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-424

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

Nav1.4 sodium channel

Target Description

Sodium channel subunit beta-1or Navbeta1 Na+ channel is encoded by SCN1B. Voltage gated sodium channels are made up of an alpha (pore forming) subunit and 1 or 2 beta subunits. SCN1B has two splice variants. Navß1 is a transmembrane protein and acts as a regulatory subunit in excitable membranes and modulates the kinetics of channel inactivation. It is found expressed in brain, spinal cord, heart and skeletal muscle. Diseases associated with SCN1B include several types of epilepsy.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N255/38

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Scn4a

Molecular Weight

>200 kDa

Antigen

Fusion protein amino acids 269-386 (Repeat I external pore between S5 and S6) of rat Nav1.4 (accession number P15390) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2716260

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Sodium channel protein type 4 subunit alpha (Mu-1) (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4)

UniProt Details

UniProt (Human): P35499
UniProt (Immunogen Species): P15390

Product Specific References for Applications and Species

Immunohistochemistry: Mouse
Western Blot: Mouse

Immunohistochemistry: Mouse
PMID	Dilution	Publication
38650308	1:1000	Butenko, O, et al. 2024. Change of voltage-gated sodium channel repertoire in skeletal muscle of a MuSK myasthenia gravis mouse model. The European Journal of Neuroscience, 3292-3308.
34289389	not listed	Zhang, C., et al. 2021. Ankyrin-dependent Na+ channel clustering prevents neuromuscular synapse fatigue. Current Biology, 3810-3819.

Western Blot: Mouse
PMID	Dilution	Publication
34289389	not listed	Zhang, C., et al. 2021. Ankyrin-dependent Na+ channel clustering prevents neuromuscular synapse fatigue. Current Biology, 3810-3819.

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Anti-Nav1.4 Sodium Channel Antibody (N255/38)

SKU: 75-424

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-Nav1.4 Sodium Channel Antibody

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