Anti-GABA-A-R, Delta Antibody (N151/3)

Name: Anti-GABA-A-R, Delta Antibody
Brand: NeuroMab
SKU: 75-171
Price: 319.0 USD
Availability: InStock

4 Citations

Our Anti-GABA(A)R, Delta mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N151/3. It detects mouse and rat GABA(A)R, Delta, and is purified by Protein A chromatography. It is great for use in ICC, WB.

Cerebellar lysate immunoblot probed with N151/3 (3 mg/mL).

Cultured rat hippocampal neuron surface (S, left) and total (T, right) protein immunofluorescence staining (green) with N151/3 (2 mg/mL).

Hippocampus immunohistochemistry with N151/3 (5 mg/mL).

Cerebellar lysate immunoblot probed with N151/3 (3 mg/mL).

Species Reactivity

Mouse, Rat

Applications

ICC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-171

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

GABA(A)R, Delta

Target Description

Gamma-aminobutyric acid receptor subunit delta or Delta GABA-A receptor is encoded by the gene GABRD. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR delta is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR delta is highly expressed in brain at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N151/3

Isotype

IgG2a

Applications

ICC, WB

Host Species

Mouse

Gene Name

Gabrd

Molecular Weight

55 kDa

Antigen

Synthetic peptide amino acids 15-34 (CTQPHHGARAMNDIGDYVGS, extracellular N-terminus) of rat GABA-A-R-Delta (accession number P18506)

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2107254

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.99

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Gamma-aminobutyric acid receptor subunit delta (GABA(A) receptor subunit delta)

UniProt Details

UniProt (Human): O14764
UniProt (Immunogen Species): P18506

Product Specific References for Applications and Species

Immunocytochemistry: Rat
Western Blot: Human | Rat

Immunocytochemistry: Rat
PMID	Dilution	Publication
23714576	20ug/ml	Joshi, S., et al. 2013. GABAA receptor membrane insertion rates are specified by their subunit composition.. Molecular and Cellular Neuroscience, 201-211.

Western Blot: Human
PMID	Dilution	Publication
38623967	1:1000	Bundy, J., et al. 2024. Role of β3 subunit of the GABA type A receptor in triple negative breast cancer proliferation, migration, and cell cycle progression. Cell Cycle, 448-465.

Western Blot: Rat
PMID	Dilution	Publication
23585058	5ug/ml	Joshi, S., et al. 2013. N-methyl-D-aspartic acid receptor activation downregulates expression of δ subunit-containing GABAA receptors in cultured hippocampal neurons.. Molecular Pharmacology, 1-11.

Additional Publications: Unspecified
PMID	Publication
21439793	Kharlamov, E.A., et al. 2011. Alterations of GABA(A) and glutamate receptor subunits and heat shock protein in rat hippocampus following traumatic brain injury and in posttraumatic epilepsy.. Epilepsy Research, 20-34.

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Anti-GABA-A-R, Delta Antibody (N151/3)

SKU: 75-171

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-GABA-A-R, Delta Antibody

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