Our Anti-Phospholipase C β2 (PLC-β2) rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human and non-human primate Phospholipase C β2 (PLC-β2) and is antigen affinity purified from pooled serum. It is great for use in IHC.
Immunostaining of human larynx taste bud showing specific labeling of PLC β2 (red) and GNAT3 (green). Photo courtesy of Mei Li, University of Colorado-Anschutz MC.
Phospholipases are quite common enzymes that are present in a broad range of organisms, including bacteria, yeast, plants, animals, and viruses. Phospholipase C (PLC) constitutes a class of enzymes that cleave phospholipids on the diacylglycerol (DAG) side of the phosphodiester bond (Cocco et al., 2015). A growing body of evidence supports the role of phospholipase C (PLC) in the invasion and metastasis of different tumors, including breast cancer (Bertagnolo et al., 2006). PLC-β2 has been shown to be required for sweet, umami and bitter taste perception in mammals (Zhang et al., 2003). Data also suggests that PLC-β2 serves an unappreciated role assembling components of the p38MAPK signaling module (Barr et al., 2002).
Antigen Affinity Purified from Pooled Serum
Polyclonal
IgG
ICC, IHC
Rabbit
PLCB2
135 kDa
Synthetic peptide corresponding to amino acid residues from the C-terminal region of human PLC β2.
Human, Non-Human Primate
AB_2801663
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Liquid
Prepared from pooled rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
IHC: 1:1000
Unconjugated
Specific for endogenous levels of PLC β2.
Immunostaining performed on each lot
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
After date of receipt, stable for at least 1 year at -20°C.
