Anti-RBPMS Antibody

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Our Anti-RBPMS primary antibody from PhosphoSolutions is rabbit polyclonal. It detects feline, guinea pig, pig, human, mouse, non-human primate, rabbit, rat, tree shrew, whale, and zebrafish RBPMS and is antigen affinity purified. It is great for use in WB, IHC, ICC.

Immunostaining of mouse retinal ganglion cells showing specific immunolabeling of RBPMS (1:1000) in red. Photo courtesy of Allen Rodriguez, University of California, Los Angeles.
Immunostaining of cat retina showing specific immunolabeling of RBPMS. Photo courtesy of Emily Brinker, Auburn University.
Western blot of rat heart lysate showing specific labeling of the ~24 kDa RBPMS protein.
Representative confocal image of a horizontal section of the macaque ganglion cell layer immunolabeled with a pan-RGC marker (RBPMS, Cat. 1830-RBPMS, white) and probed by RNA in situ hybridization for BNC2 (green) and FSTL4 (red) mRNA. Nuclei are counterstained with DAPI. Image from publication CC-BY-4.0. 
Whole mount whale retina labelled with RBPMS (red) to label RGCs. Image from publication CC-BY-4.0. PMID: 35185483
Immunostaining of retinas in control, I/R, I/R+DMSO and I/R+VAL groups, stained with DAPI (blue), RBPMS (green) and TUNEL (red). Image from publication CC-BY-4.0. PMID: 36361772
Representative confocal image of macaque GCL immunolabelled for BNC2, FOXP2 and RBPMS (cat. 1830-RBPMS). Image from publication CC-BY-4.0. PMID: 37880369
Human ganglion cell layer (GCL) labelled for BNC2 and RBPMS (cat. 1830-RBPMS) with example RGC11 cells in ROIs. ROI 1 and ROI 2 are shown enlarged on the right. Images in b were 2D median filtered before maximal z-projection of the GCL. Image from publication CC-BY-4.0. PMID: 37880369
Immunostaining of mouse retinal ganglion cells showing specific immunolabeling of RBPMS (1:1000) in red. Photo courtesy of Allen Rodriguez, University of California, Los Angeles.
Immunostaining of mouse retinal ganglion cells showing specific immunolabeling of RBPMS (1:1000) in red. Photo courtesy of Allen Rodriguez, University of California, Los Angeles.
Immunostaining of cat retina showing specific immunolabeling of RBPMS. Photo courtesy of Emily Brinker, Auburn University.
Western blot of rat heart lysate showing specific labeling of the ~24 kDa RBPMS protein.
Representative confocal image of a horizontal section of the macaque ganglion cell layer immunolabeled with a pan-RGC marker (RBPMS, Cat. 1830-RBPMS, white) and probed by RNA in situ hybridization for BNC2 (green) and FSTL4 (red) mRNA. Nuclei are counterstained with DAPI. Image from publication CC-BY-4.0. 
Whole mount whale retina labelled with RBPMS (red) to label RGCs. Image from publication CC-BY-4.0. PMID: 35185483
Immunostaining of retinas in control, I/R, I/R+DMSO and I/R+VAL groups, stained with DAPI (blue), RBPMS (green) and TUNEL (red). Image from publication CC-BY-4.0. PMID: 36361772
Representative confocal image of macaque GCL immunolabelled for BNC2, FOXP2 and RBPMS (cat. 1830-RBPMS). Image from publication CC-BY-4.0. PMID: 37880369
Human ganglion cell layer (GCL) labelled for BNC2 and RBPMS (cat. 1830-RBPMS) with example RGC11 cells in ROIs. ROI 1 and ROI 2 are shown enlarged on the right. Images in b were 2D median filtered before maximal z-projection of the GCL. Image from publication CC-BY-4.0. PMID: 37880369

Feline, Guinea Pig, Human, Mouse, Non-Human Primate, Pig, Rabbit, Rat, Tree Shrew, Whale, Zebrafish
ICC, IHC, WB
Rabbit

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SKU: 1830-RBPMS

Volume: 100 µL
1-2 business days
Price:
$430.00

Product Specific References for Applications and Species

Flow Cytometry: Human Stem Cells
PMID Dilution Publication
27826002 1:400 Hunt, N.C., et al. 2017. 3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development. Acta Biomaterialia, 49, pp. 329-343.
Immunocytochemistry: Human Stem Cells
PMID Dilution Publication
27826002 1:200 Hunt, N.C., et al. 2017. 3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development. Acta Biomaterialia, 49, pp. 329-343.
Immunocytochemistry: Mouse RCG’s
PMID Dilution Publication
32523990 1:500 Xiao, D., et al. 2020. Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts. Science Advances, 6(22), p.eaaz5858.
30796289 1:250 Park, Y.H., et al. 2019. Transcriptomic profiles of retinal ganglion cells are defined by the magnitude of intraocular pressure elevation in adult mice. Scientific Reports, 9(1), p.2594.
Immunocytochemistry: Rat
PMID Dilution Publication
27826002 1:300 Galvao, J., et al. 2018. The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration. Investigative Ophthalmology & Visual Science, 59(7), pp.2736-2747.
Immunohistochemistry: Human
PMID Dilution Publication
36640318not listedGuo, C., et al. 2023. HIF-1α Accumulation in Response to Transient Hypoglycemia May Worsen Diabetic Eye Disease. Cell Reports, 111976.
361488761:200Laurinaviciute, G., et al. 2022. Maternal Undernutrition Model of Two Generations of Rats: Changes in the Aged Retina. Histology and Histopathology, 18522.
32531194 1:500 VanderWall, K.B., et al. 2020. Retinal Ganglion Cells With a Glaucoma OPTN (E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids. Stem Cell Reports, 15(1), pp 52-66.
Immunohistochemistry: Guinea Pig
PMID Dilution Publication
31896668 1:500 Puller, C., et al. 2020. Electrical coupling of heterotypic ganglion cells in the mammalian retina. Journal of Neuroscience, 40(6), pp.1302-1310.
Immunohistochemistry: Mouse
PMID Dilution Publication
385443611:500Su, J, et al. 2024. Distribution, development, and identity of retinal ganglion cells labeled in the Sert-Cre reporter mouse. The Journal of Comparative Neurology, e25606.
38492223not listedPassino, R, et al. 2024. Neutrophil-inflicted vasculature damage suppresses immune-mediated optic nerve regeneration. Cell Reports, 113931.
375614491:500Lakshmanan, Y, et al. 2023. Long-Term Effects on Retinal Structure and Function in a Mouse Endothelin-1 Model of Retinal Ganglion Cell Degeneration. Investigative Ophthalmology & Visual Science, 15.
373646291:500Balraj, A, et al. 2023. Loss of Optic Nerve Oligodendrocytes During Maturation Alters Retinal Organization. Experimental Eye Research, 109540.
370152881:500de Montigny, .J, et al. 2023. Retinal Self-Organization: A Model of Retinal Ganglion Cells and Starburst Amacrine Cells Mosaic Formation. Open Biology, 220217.
362616831:200Noro, T., et al. 2022. Elk-1 Regulates Retinal Ganglion Cell Axon Regeneration After Injury. Scientific Reports, 17446.
360780971:250Claes, M., et al. 2022. Retinal Ganglion Cells: Global Number, Density and Vulnerability to Glaucomatous Injury in Common Laboratory Mice. Cells, 2689.
35259089 1:300 Shah, S.H., et al. 2022. Quantitative transportomics identifies Kif5a as a major regulator of neurodegeneration. Elife, 11.
34801667 1:1000 Di Pierdomenico, J., et al. 2021. Age and intraocular pressure in murine experimental glaucoma. Progress in retinal and eye research, p.101021.
34649511 1:200 Ayupe, A.C., et al. 2021. Identification of long noncoding RNAs in injury-resilient and injury-susceptible mouse retinal ganglion cells. BMC genomics, 22(1), pp.1-16.
34350994 1:500 Sundberg, C.A, et al. 2021. The RNA-binding protein and stress granule component ATAXIN-2 is expressed in mouse and human tissues associated with glaucoma pathogenesis. Journal of Comparative Neurology.
34363035 1:50 Visuvanathan, S., et al. 2021. XIAP gene therapy effects on retinal ganglion cell structure and function in a mouse model of glaucoma. Gene therapy, pp.1-10.
34193509 not listed Johnson, K.O., et al. 2021. NMDA Receptor Expression by Retinal Ganglion Cells Is Not Required for Retinofugal Map Formation nor Eye-Specific Segregation in the Mouse. Eneuro, 8(4).
33657370 1:500 Lindborg, J.A., et al. 2021. Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Cell Reports, 34(9), p.108777.
33531684 not listed Korecki, A.J., et al. 2021. Human MiniPromoters for ocular-rAAV expression in ON bipolar, cone, corneal, endothelial, Müller glial, and PAX6 cells. Gene Therapy, pp.1-22.
33135183 1:500 Parmhans, N., et al. 2020. Identification of retinal ganglion cell types and brain nuclei expressing the transcription factor Brn3c/Pou4f3 using a Cre recombinase knock‐in allele. Journal of Comparative Neurology.
33027659 1:500 Louail, A., et al. 2020. cAMP-Dependent Co-stabilization of Axonal Arbors from Adjacent Developing Neurons. Cell Reports, 33(1), p.108220.
33441400 1:500 Chang, K.C., et al. 2021. Post-translational modification of Sox11 regulates RGC survival and axon regeneration. Eneuro, Jan 12. ENEURO.0358-20.2020.
33436866 1:250 Masin, L., et al. 2021. A novel retinal ganglion cell quantification tool based on deep learning. Scientific Reports, 11(1), pp.1-13.
33410914 1:500 Harrison, K.R., et al. 2021. Amacrine Cells Forming Gap Junctions With Intrinsically Photosensitive Retinal Ganglion Cells: ipRGC Types, Neuromodulator Contents, and Connexin Isoform. Investigative Ophthalmology & Visual Science, 62(1), pp.10-10.
33156340 1:100 Kobayashi-Otsugu, M., et al. 2020. Activation of Cytosolic Calpain, Not Caspase, Is Underlying Mechanism for Hypoxic RGC Damage in Human Retinal Explants. Investigative Ophthalmology & Visual Science, 61(13), pp.13-13.
32858248 1:500 Rodriguez, L., et al. 2020. Tau modulates visual plasticity in adult and old mice. Neurobiology of Aging, 95, pp.214-224.
32821777 1:250 Shen, G., et al. 2020. Modeling a potential SANS countermeasure by experimental manipulation of the translaminar pressure difference in mice. NPJ Microgravity, 6(1), pp.1-9.
32788726 1:500 Alarcon-Martinez, L., et al. 2020. Interpericyte tunnelling nanotubes regulate neurovascular coupling. Nature, 585(7823), pp.91-95.
32735323 1:100 Wassmer, S.J., et al. 2020. XIAP Protects Retinal Ganglion Cells in the Mutant ND4 Mouse Model of Leber Hereditary Optic Neuropathy. Investigative Ophthalmology & Visual Science, 61(8), pp.49-49.
32579912 1:500 Guttenplan, K.A., et al. 2020. Neurotoxic reactive astrocytes drive neuronal death after retinal injury. Cell Reports, 31(12), p.107776.
32523990 1:500 Xiao, D., et al. 2020. Xiao, D., Deng, Q., Guo, Y., Huang, X., Zou, M., Zhong, J., Rao, P., Xu, Z., Liu, Y., Hu, Y. and Shen, Y., 2020. Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts. Science Advances, 6(22), p.eaaz5858.
32521255 not listed Care, R.A., et al. 2020. Mature Retina Compensates Functionally for Partial Loss of Rod Photoreceptors. Cell Reports, 31(10), p.107730.
32238415 1:500 Webster, C.M., et al. 2020. Steroid activation of TRPM3 channels modulates spontaneous synaptic activity but not retinal waves in the developing retina. Eneuro, Mar 27;ENEURO.0175-19.2020.
32029703 1:200 Mdzomba, J.B., et al. 2020. Nogo-A-targeting antibody promotes visual recovery and inhibits neuroinflammation after retinal injury. Cell Death & Disease, 11(2), pp.1-16.
31964831 1:500 Su, J., et al. 2020. Retinal inputs signal astrocytes to recruit interneurons into visual thalamus. Proceedings of the National Academy of Sciences, 117(5), pp.2671-2682.
31811649 1:500 Stefanov, A., et al. 2019. Inner Retinal Preservation in the photo‐inducible I307N Rhodopsin Mutant Mouse, a Model of Autosomal Dominant Retinitis Pigmentosa. Journal of Comparative Neurology, 528(9), pp. 1502-1522.
31775817 1:1000 Welsbie, D.S, et al. 2019. Targeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury. Molecular Neurodegeneration, 14(1), p.44.
31255486 not listed Bray, E.R, et al. 2019. Thrombospondin-1 Mediates Axon Regeneration in Retinal Ganglion Cells. Neuron, 103(4)
31108505 1:500 Lupori, L., et al. 2019. Site-specific abnormalities in the visual system of a mouse model of CDKL5 deficiency disorder. Human Molecular Genetics, 28(17), pp.2851-2861.
31091454 not listed Care, R.A., et al. 2019. Partial Cone Loss Triggers Synapse-Specific Remodeling and Spatial Receptive Field Rearrangements in a Mature Retinal Circuit. Cell Reports, 27(7), pp.2171-2183.
31042799 1:200 Alarautalahti, V., et al. 2019. Viability of Mouse Retinal Explant Cultures Assessed by Preservation of Functionality and Morphology. Investigative Ophthalmology and Visual Science, 60(6), pp.1914-1927.
30831136 1:200 Hikida, T., et al. 2020. Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice. Neuroscience Research, 151, pp.38-45.
30392793 not listed Tiriac, A., et al. 2018. Light Prior to Eye Opening Promotes Retinal Waves and Eye-Specific Segregation. Neuron, 100(5), pp. 1059-1065.
30062914 1ug/ul Simpson, E., et al. 2019. New MiniPromoter Ple345 (NEFL) Drives Strong and Specific Expression in Retinal Ganglion Cells of Mouse and Primate Retina. Human Gene Therapy, 30(3), pp.257-272.
29950598 1:200 Mdzomba, J.B., et al. 2018. Nogo-A inactivation improves visual plasticity and recovery after retinal injury. Cell Death & Disease, 9(7), p.727.
29931057 1:1000 Agostinone, J., et al. 2018. Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury. Brain, 141(7), pp. 1963-1980.
29434244 1:250 Shen, G., et al. 2018. Characterization of Retinal Ganglion Cell and Optic Nerve Phenotypes Caused by Sustained Intracranial Pressure Elevation in Mice. Scientific Reports, 8(1), p.2856.
29241535 1:2000 Seabrook, T.A., et al. 2017. Strict Independence of Parallel and Poly-synaptic Axon-Target Matching during Visual Reflex Circuit Assembly. Cell Reports, 21(11), pp.3049-3064.
29106385 not listed Livne-Bar, I., et al. 2017. Astrocyte-derived lipoxins A 4 and B 4 promote neuroprotection from acute and chronic injury. The Journal of Clinical Investigation, 127(12), pp. 4403-4414.
29067402 1:500 Liang, C., et al. 2017. Optic nerve hypoplasia is a pervasive subcortical pathology of visual system in neonates. Investigative Ophthalmology & Visual Science, 58(12), pp.5485-5496.
28871032 1:300 Apara, A., et al. 2017. KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS. Journal of Neuroscience, 37(40), pp.9632-9644.
28774322 1:1000 Chiasseu, M., et al. 2017. Tau accumulation in the retina promotes early neuronal dysfunction and precedes brain pathology in a mouse model of Alzheimer’s disease. Molecular Neurodegeneration, 12(1), p.58.
28607486 1:500 Sabbah, S., et al. 2017. A retinal code for motion along the gravitational and body axes. Nature, 546(7659), pp.492-497.
28607399 1:500 Assali, A., et al. 2017. RIM1/2 are required in retinal ganglion cells for the refinement of ipsilateral axons and eye-specific segregation. Scientific Reports, 7(1), p. 3236.
28262325 1:200 Joly, S., et al. 2017. Non-amyloidogenic processing of amyloid beta precursor protein is associated with retinal function improvement in aging male APP swe/PS1ΔE9 mice. Neurobiology of Aging, 53, pp. 181-191.
28099414 1:500 Liddelow, S.A., et al. 2017. Neurotoxic reactive astrocytes are induced by activated microglia. Nature, 541(7638), p.481-487.
27699209 not listed Ueki, Y., et al. 2016. Loss of Ikbkap causes slow, progressive retinal degeneration in a mouse model of familial dysautonomia. eNeuro, 3(5).
27685630 not listed Livne-Bar, I., et al. 2016. Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis. Cell Death and Disease, 7(9), e2386.
27654429 1:400 Chen, L. et al. 2016. Heterozygous Pitx2 Null Mice Accurately Recapitulate the Ocular Features of Axenfeld-Rieger Syndrome and Congenital Glaucoma. Investigative Ophthalmology and Visual Science, 57(11), pp.5023-5030.
27399843 1:1000 Lim, J. H. A., et al. 2016. Neural activity promotes long-distance, target-specific regeneration of adult retinal axons. Nature Neuroscience, 19(8), 1073-84.
Immunohistochemistry: Non-human Primate
PMID Dilution Publication
37880369not listedWang, AYM, et al. 2023. An ON-type direction-selective ganglion cell in primate retina. Nature, 381-386.
34547460 1:500 McGregor, J.E., et al 2021. Optogenetic therapy restores retinal activity in primate for at least a year following photoreceptor ablation. Molecular Therapy.
29954626 1:100 Sauter, M.M., et al 2018. Toll-like receptors 4, 5, 6 and 7 are constitutively expressed in non-human primate retinal neurons. Journal of Neuroimmunology, 322, pp. 26-35.
Immunohistochemistry: Pig
PMID Dilution Publication
35078337 not listed Chan, D., et al 2022. Application of an organotypic ocular perfusion model to assess intravitreal drug distribution in human and animal eyes. Journal of the Royal Society Interface, 19(186), p.20210734
34038912 1:100 Svare, F., et al 2021. It’s About Time: Time-Dependent Tissue Damage in the Adult Porcine Retina After Enucleation. Cells Tissues Organs, 210(1), pp.58-65
Immunohistochemistry: Rat
PMID Dilution Publication
363617721:200Gao, Z., et al. 2022. Valdecoxib Protects Against Cell Apoptosis Induced By Endoplasmic Reticulum Stress Via The Inhibition Of PERK-ATF4-CHOP Pathway In Experimental Glaucoma. International Journal Of Molecular Sciences, 12983.
35259089 1:300 Shah, S.H., et al. 2022. Quantitative transportomics identifies Kif5a as a major regulator of neurodegeneration. Elife, 11.
34753986 not listed Geva, M., et al. 2021. Neuroprotection of retinal ganglion cells by the sigma-1 receptor agonist pridopidine in models of experimental glaucoma. Scientific Reports, 11(1), pp.1-16.
34283208 1:500 Do, J.L., et al. 2021. Optic Nerve Engraftment of Neural Stem Cells. Investigative ophthalmology & visual science, 62(9), pp.30-30.
33154382 1:500 Petrova, V., et al. 2020. Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS. Nature communications, 11(1), pp.1-15.
32579912 1:500 Guttenplan, K.A., et al. 2020. Neurotoxic reactive astrocytes drive neuronal death after retinal injury. Cell Reports, 31(12), p.107776.
31369591 1:500 Choi, B.K., et al. 2019. Stabilization of primary cilia reduces abortive cell cycle re-entry to protect injured adult CNS neurons from apoptosis. PloS one, 14(8), p.e0220056.
30837658 1:250 van der Merwe, Y., et al. 2019. Matrix-bound nanovesicles prevent ischemia-induced retinal ganglion cell axon degeneration and death and preserve visual function. Scientific Reports, 9(1), p. 3482.
29860460 1:300 Galvao, J., et al. 2018. The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration. Investigative Ophthalmology & Visual Science, 59(7), pp.2736-2747.
27163643 1ug/ml Vargas, J. L. C., et al. 2016. The glial cell modulator ibudilast attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma through protein kinase A signaling. Neurobiology of Disease, 93, pp. 156-171.
26539914 1:500 Shabanzadeh, A. P., et al. 2015. Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke. Cell Death and Disease, 6(11), e1967.
26338321 0.1ug/ml Vargas, J. L. C., et al. 2015. Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation. The Journal of Neuroscience, 35(35), pp. 12088-12102.
25450063 1:300 Reifler, A. N., et al. 2015. The rat retina has five types of ganglion-cell photoreceptors. Experimental Eye Research, 130, pp. 17-28.
Immunohistochemistry: Tree Shrew
PMID Dilution Publication
29238991 1:500 Johnson, E.N., et al. 2019. Distribution and diversity of intrinsically photosensitive retinal ganglion cells in tree shrew. Journal of Comparative Neurology, 527(1), pp.328-344.
Immunohistochemistry: Whale
PMID Dilution Publication
35185483 1:4000 Ruzafa, N., et al. 2022. Immunohistochemical Characterisation of the Whale Retina. Frontiers in Neuroanatomy, 16, 813369.
Immunohistochemistry: Zebrafish
PMID Dilution Publication
293788631:300Elsaeidi, F., et al. 2018. Notch Suppression Collaborates With Ascl1 and Lin28 to Unleash a Regenerative Response in Fish Retina, But Not in Mice. Journal of Neuroscience, .
303824661:100Van Houcke, J., et al. 2019. Extensive Growth Is Followed by Neurodegenerative Pathology in the Continuously Expanding Adult Zebrafish Retina. Biogerontology, .

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