Anti-Integrin alpha-M (CD11b, MAC-1, OX-42 Antigen) Antibody

1 Citation

Our anti-Integrin Alpha-M (MAC-1) antibody was purified from eggs collected from chickens injected with a KLH-conjugated peptide corresponding to a sequence shared between the mouse (NP_001076429.1) and human gene products (NP_001139280.1). These antibodies have been validated with human, mouse and rat tissues.

Low-power view of MAC1 immunoreactivity in microglial cells in a paraformaldehyde (4%)-fixed paraffin-embedded section through cerebral cortex of an adult mouse brain. 1˚ antibody was Aves Labs' anti-MAC1 antibody (1:2000 dilution); 2˚ antibody was a Texas Red goat anti-chicken IgY (Jackson ImmunoResearch; 1:1000 dilution).
Higher-power view of MAC1 immunoreactivity in microglial cells in a paraformaldehyde (4%)-fixed paraffin-embedded section through cerebral cortex of an adult mouse brain. 1˚ antibody was Aves Labs' anti-MAC1 antibody (1:2000 dilution); 2˚ antibody was a Texas Red goat anti-chicken IgY (Jackson ImmunoResearch; 1:1000 dilution).
Frame showing MAC-1 immunoreactivity in human microglial cells in an Alzheimer's Disease patient. Photomicrograph taken by Dr. Randy Woltjer, Pathology, OHSU.
Frame showing MAC-1 immunoreactivity in human microglial cells in an Alzheimer's Disease patient. Photomicrograph taken by Dr. Randy Woltjer, Pathology, OHSU.
Low-power view of MAC1 immunoreactivity in microglial cells in a paraformaldehyde (4%)-fixed paraffin-embedded section through cerebral cortex of an adult mouse brain. 1˚ antibody was Aves Labs' anti-MAC1 antibody (1:2000 dilution); 2˚ antibody was a Texas Red goat anti-chicken IgY (1:1000 dilution).
Higher power view of MAC1 immunoreactivity in microglial cells in a paraformaldehyde (4%)-fixed paraffin-embedded section through cerebral cortex of an adult mouse brain, (1:2000 dilution). 2˚ antibody was a Texas Red goat anti-chicken IgY (1:1000 dilution).
Frame showing MAC-1 immunoreactivity in human microglial cells in an Alzheimer's Disease patient. Photomicrograph taken by Dr. Randy Woltjer, Pathology, OHSU.
Frame showing MAC-1 immunoreactivity in human microglial cells in an Alzheimer's Disease patient. Photomicrograph taken by Dr. Randy Woltjer, Pathology, OHSU.
Low-power view of MAC1 immunoreactivity in microglial cells in a paraformaldehyde (4%)-fixed paraffin-embedded section through cerebral cortex of an adult mouse brain. 1˚ antibody was Aves Labs' anti-MAC1 antibody (1:2000 dilution); 2˚ antibody was a Texas Red goat anti-chicken IgY (Jackson ImmunoResearch; 1:1000 dilution).
Low-power view of MAC1 immunoreactivity in microglial cells in a paraformaldehyde (4%)-fixed paraffin-embedded section through cerebral cortex of an adult mouse brain. 1˚ antibody was Aves Labs' anti-MAC1 antibody (1:2000 dilution); 2˚ antibody was a Texas Red goat anti-chicken IgY (Jackson ImmunoResearch; 1:1000 dilution).
Higher-power view of MAC1 immunoreactivity in microglial cells in a paraformaldehyde (4%)-fixed paraffin-embedded section through cerebral cortex of an adult mouse brain. 1˚ antibody was Aves Labs' anti-MAC1 antibody (1:2000 dilution); 2˚ antibody was a Texas Red goat anti-chicken IgY (Jackson ImmunoResearch; 1:1000 dilution).
Frame showing MAC-1 immunoreactivity in human microglial cells in an Alzheimer's Disease patient. Photomicrograph taken by Dr. Randy Woltjer, Pathology, OHSU.
Frame showing MAC-1 immunoreactivity in human microglial cells in an Alzheimer's Disease patient. Photomicrograph taken by Dr. Randy Woltjer, Pathology, OHSU.
Low-power view of MAC1 immunoreactivity in microglial cells in a paraformaldehyde (4%)-fixed paraffin-embedded section through cerebral cortex of an adult mouse brain. 1˚ antibody was Aves Labs' anti-MAC1 antibody (1:2000 dilution); 2˚ antibody was a Texas Red goat anti-chicken IgY (1:1000 dilution).
Higher power view of MAC1 immunoreactivity in microglial cells in a paraformaldehyde (4%)-fixed paraffin-embedded section through cerebral cortex of an adult mouse brain, (1:2000 dilution). 2˚ antibody was a Texas Red goat anti-chicken IgY (1:1000 dilution).
Frame showing MAC-1 immunoreactivity in human microglial cells in an Alzheimer's Disease patient. Photomicrograph taken by Dr. Randy Woltjer, Pathology, OHSU.
Frame showing MAC-1 immunoreactivity in human microglial cells in an Alzheimer's Disease patient. Photomicrograph taken by Dr. Randy Woltjer, Pathology, OHSU.

Human, Mouse, Rat
ICC, IHC, WB
Chicken

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Data Sheet

SKU: MAC

Volume: 1000 µL
Price:
$455.00

Product Specific References for Applications and Species

  • Flow Cytometry: Rat
  • Immunocytochemistry: Rat
  • Immunohistochemistry: Rat
Flow Cytometry: Rat
PMID Dilution Publication
297400621:500Merlo, S., et al. 2018. The contribution of microglia to early synaptic compensatory responses that precede β-amyloid-induced neuronal death. Scientific Reports, 7297.
Immunocytochemistry: Rat
PMID Dilution Publication
297400621:80Merlo, S., et al. 2018. The contribution of microglia to early synaptic compensatory responses that precede β-amyloid-induced neuronal death. Scientific Reports, 7297.
Immunohistochemistry: Rat
PMID Dilution Publication
297400621:80Merlo, S., et al. 2018. The contribution of microglia to early synaptic compensatory responses that precede β-amyloid-induced neuronal death. Scientific Reports, 7297.

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