Anti-Pink1 PTEN Induced Putative Kinase 1 Antibody (N4/15)

Name: Anti-Pink1 PTEN Induced Putative Kinase 1 Antibody
Brand: NeuroMab
SKU: 75-060
Price: 319.0 USD
Availability: InStock

4 Citations

Our Anti-Pink1 PTEN induced putative kinase 1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N4/15. It detects human, mouse, and rat Pink1 PTEN induced putative kinase 1, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Adult rat brain immunohistochemistry (with antigen retrieval via sodium citrate pretreatment).

Adult rat brain low-speed pellet immunoblot.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-060

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

Pink1 PTEN induced putative kinase 1

Target Description

PTEN Induced Kinase 1 is encoded by the gene PINK1. PINK1 is a member of the protein kinase superfamily, Ser/Thr protein kinase family. PINK1 is a serine/threonine protein kinase that protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. PINK1 is highly expressed in the heart, skeletal muscle, and testis. Diseases associated with PINK1 include Parkinson Disease 6, Autosomal Recessive Early-Onset and Parkinson Disease 2, Autosomal Recessive Juvenile.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N4/15

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

PINK1

Molecular Weight

63 kDa

Antigen

Fusion protein amino acids 112-496 of human Pink1 (accession number NP_115785) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10676107

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)

UniProt Details

UniProt (Human): Q9BXM7
UniProt (Immunogen Species): Q9BXM7

Product Specific References for Applications and Species

Immunocytochemistry: Mouse
Western Blot: Human | Mouse

Immunocytochemistry: Mouse
PMID	Dilution	Publication
22910362	1:200	Okatsu, K., et al. 2012. PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria.. Nature Communications, 1016.

Western Blot: Human
PMID	Dilution	Publication
18687899	not listed	Zhou, C., et al. 2008. The kinase domain of mitochondrial PINK1 faces the cytoplasm.. PNAS USA, 12022-12027.

Western Blot: Mouse
PMID	Dilution	Publication
29128334	not listed	Malty, R.H., et al. 2017. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. Cell Systems, 564-577.
28522732	1:500	Henderson, M.X., et al. 2017. Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies. Journal of Neuroscience, 5870-5884.

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Anti-Pink1 PTEN Induced Putative Kinase 1 Antibody (N4/15)

SKU: 75-060

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-Pink1 PTEN Induced Putative Kinase 1 Antibody

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