Anti-FLASH (C-terminus) Antibody

Name: Anti-FLASH (C-terminus) Antibody
Brand: PhosphoSolutions
SKU: 24168
Price: 430.0 USD
Availability: InStock

Our FLASH rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human FLASH and is antigen affinity purified. It is great for use in WB.

Western Blot of NIH3T3 cell lysate showing specific immunolableing of FLASH.

Species Reactivity

Human

Applications

Host Species

Rabbit

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SKU: 24168

Title: 100 µL

Variant

Price:

$430.00

Quantity:

Product Details

Target

FLASH

Target Description

Fas is a cell-surface receptor molecule that relays apoptotic (cell death) signals into cells. When Fas is activated by binding of its ligand, the proteolytic protein caspase-8 is recruited to a signalling complex known as DISC by binding to a Fas-associated adapter protein. A new protein, FLASH, contains a motif with oligomerizing activity whose sequence is similar to that of the Caenorhabditis elegans protein CED-4, and another domain (DRD domain) that interacts with a death-effector domain in caspase-8 or in the adapter protein. FLASH is likely a component of the DISC signalling complex and is necessary for the activation of caspase-8 in Fas-mediated apoptosis.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

Host Species

Rabbit

Gene Name

CASP8AP2

Antigen

Synthetic peptide corresponding to amino acids from the C-terminal region of human FLASH protein

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the C-terminal region of human FLASH protein

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

CASP8-associated protein 2, CASP8AP, FLICE-associated huge protein, CED4, RIP25

UniProt Details

UniProt (Human): Q9UKL3
UniProt (Immunogen Species): Q9UKL3

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Anti-FLASH (C-terminus) Antibody

SKU: 24168

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