Anti-mOPN4 (Melanopsin) Antibody

Name: Anti-mOPN4 (Melanopsin) Antibody
Brand: Aves Labs
SKU: mOPN4-0100
Price: 455.0 USD
Availability: InStock

Our Anti-Mouse Opsin 4/Melanopsin chicken polyclonal primary antibody from Aves Labs is produced in-house. It detects mOPN4, and is affinity-purified IgY. It is great for use in ICC.

Immunofluorescence staining of melanopsin in mouse retinal tissue using mOPN4 chicken antibody (Cat No. mOPN4-0100).

Species Reactivity

Mouse

Applications

ICC

Host Species

Chicken

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Data Sheet

Trial Size

SKU: mOPN4-0100

Volume: 500 µL

Variant

Price:

$455.00

Quantity:

Product Details

Target

Mouse Opsin 4/Melanopsin

Target Description

The melanopsin protein (mOPN4), encoded by the OPN4 gene, is a photopigment found in specialized retinal ganglion cells (Hughes et al. 2016). mOPN4 plays a crucial role in non-image-forming visual processes, including the regulation of circadian rhythms, pupillary light reflex, and mood modulation (Pan et al. 2023 and Roecklein et al. 2009). Unlike rod and cone photoreceptors responsible for traditional image formation, mOPN4-expressing cells respond to light intensity and are key to synchronizing the body’s internal clock with environmental light-dark cycles. Disruptions in mOPN4 signaling are linked to various disorders, such as seasonal affective disorder, sleep disturbances, and even metabolic conditions. Research in recent years has revealed OPN4’s role in the photosensitive system of human skin (Sua-Cespedes et al 2023, Kusumoto et al. 2020), and it is even implicated in cutaneous melanoma (de Assis et al. 2022).

Format

Affinity-Purified IgY

Concentration

200 µg/mL

Clonality

Polyclonal

Isotype

IgY

Applications

ICC

Host Species

Chicken

Gene Name

OPN4

Molecular Weight

57 kDa

Antigen

Synthetic peptide

Species Reactivity

Mouse

Antibody Registry ID

AB_3665365

Storage

Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile. For longer term storage, aliquot and freeze to avoid freeze-thaw of the antibody.

Physical State

Liquid

Production Notes

Eggs from hens hyperimmunized with target were used to prepare an IgY fraction which was then subjected to antigen-specific affinity purification

Buffer

Phosphate-buffered (10 mM) isotonic (0.9%, w/v) saline (“PBS," pH 7.2) with sodium azide (0.02%, w/v) added as a preservative.

Dilution Ranges

ICC: 1:1000-1:10,000

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested via ICC to confirm that it recognizes melanopsin in the retina of C57BL6/J mice.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from receipt of product

Shipping

Ice packs

Synonyms

Opsin 4, Melanopsin, MOP

UniProt Details

UniProt (Immunogen Species): Q9QXZ9

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Anti-mOPN4 (Melanopsin) Antibody

SKU: mOPN4-0100

Product Details

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