Anti-SAP30L Antibody

Name: Anti-SAP30L Antibody
Brand: PhosphoSolutions
SKU: 24371
Price: 430.0 USD
Availability: InStock

Our SAP30L rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human SAP30L and is antigen affinity purified. It is great for use in WB.

Western Blot of GST-hSAP30L fusion protein in NIH3T3 cells (Lane 1), wild-type transfected hSAP30L (Lane 2), and endogenous hSAP30L in non-transfected MCF-7 cells showing specific immunolabeling of SAP30L.

Species Reactivity

Human

Applications

Host Species

Rabbit

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SKU: 24371

Title: 100 µL

Variant

Price:

$430.00

Quantity:

Product Details

Target

SAP30L

Target Description

A novel TGF- beta up-regulated mRNA species, the Sin3-associated protein 30-like, SAP30L has been identified. The predicted nuclear localization signal of SAP30L is sufficient for nuclear transport of the protein although mutating it does not completely remove SAP30L from the nuclei. By reason of its nuclear localization and close homology to SAP30 it is thought that SAP30L might have a role in recruiting the Sin3-histone deacetylase complex to specific co-repressor complexes in response to TGF-beta, leading to the silencing of proliferation-driving genes in the differentiating intestinal epithelial cells.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

Host Species

Rabbit

Gene Name

SAP30L

Antigen

Synthetic peptide corresponding to amino acids from the C-terminal region of human SAP30L.

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the C-terminal region of human SAP30L. Detects wild-type transfected hSAP30L or GST-hSAP30L fusion protein as well as endogenous hSAP30L in human cell lines (e.g., HEK293 and MCF-7 cells). Detects wild-type transfected hSAP30L or GST-hSAP30L fusion protein in non-human cell lines (e.g., NIH3T3 cells), but does not detect endogenous non-human SAP30L. The transfected wild-type hSAP30L runs with an apparent molecular weight of ~30kDa and the endogenous hSAP30L band runs with an apparent molecular weight of 21-22 kDa. The difference in the size of the bands is unknown, but is seen by investigators in all studies of hSAP30L. Possible explanations for the size difference may be to cleavage product, degradation and/or product or post-translational modification.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

Histone deacetylase complex subunit SAP30L, HCV non-structural protein 4A-transactivated protein 2, Sin3 corepressor complex subunit SAP30L, Sin3-associated protein p30-like

UniProt Details

UniProt (Human): Q9HAJ7
UniProt (Immunogen Species): Q9HAJ7

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Anti-SAP30L Antibody

SKU: 24371

Product Details

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