Anti-SAPAP1 Antibody (N238/29)

Name: Anti-SAPAP1 Antibody
Brand: NeuroMab
SKU: 75-466
Price: 319.0 USD
Availability: InStock

Our Anti-SAPAP1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N238/29. It detects human, mouse, and rat SAPAP1, and is purified by Protein A chromatography. It is great for use in ICC, WB.

Adult rat brain membrane (RBM) immunoblot.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-466

Product Details

Target

SAPAP1

Target Description

SAPAP1 (also known as disks large associated protein 1, DAP-1, or DLGAP1) is a member of the SAPAP or DLGAP family of proteins. SAPAP1 is part of the scaffold in neuronal cells of the brain and is a component of the postsynaptic complex. SAPAP1 acts as an adaptor protein that binds synaptic scaffold proteins, cytoskeletal proteins and signaling proteins including PSD-95 and SHANK. SAPAP1 is expressed in neurons of the cortex, hippocampus and in Purkinje cells in the cerebellum. Diseases associated with DLGAP1 include Retinitis Pigmentosa 55 and Obsessive-Compulsive Disorder

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N238/29

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

DLGAP1 DAP1 GKAP

Molecular Weight

110 kDa (varies due to post-translational modifications)

Antigen

Fusion protein amino acids 772-992 (C-terminus) of rat SAPAP1 (accession number P97836) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2651162

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Dilution Ranges

WB: 1:1000

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Disks large-associated protein 1 (SAPAP1) SAPAP-1

UniProt Details

UniProt (Human): O14490
UniProt (Immunogen Species): P97836

Product Specific References for Applications and Species

Western Blot: Mouse

Western Blot: Mouse
PMID	Dilution	Publication
33229412	not listed	Pandian, S., et al. 2020. Myosin Va Brain-Specific Mutation Alters Mouse Behavior and Disrupts Hippocampal Synapses. eNeuro, .
24795561	1:1000	Lugo, J.N., et al. 2014. Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins.. Frontiers in Molecular Neuroscience, 27.

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Anti-SAPAP1 Antibody (N238/29)

SKU: 75-466

Product Details

Product Specific References for Applications and Species

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