Anti-Shank3 Antibody FL490 Conjugate (N367/62)
Our Anti-Shank3 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N367/62. It detects mouse and rat Shank3, and is purified by Protein A chromatography. It is great for use in IHC, ICC.
SKU: 75-344-FL490
Product Details
Shank3
SH3 and multiple ankyrin repeat domains protein 3, or shank 3 (also known as proline-rich synapse-associated protein 2 (ProSAP2)) is a member of the shank family. Shank 3 binding domains include a SH3 domain, a proline rich domain, a PDZ domain and ankyrin repeat domains. Shank 3 is found in many tissues including heart and spleen, but is most abundantly expressed in brain at the post synaptic density. Shank 3 acts as a scaffold protein anchoring and connecting membrane bound receptors, ion channels and other proteins to the cytoskeleton in neurons to enable cell signaling. In this manner, Shank 3 may play a role in synapse formation and dendritic spine maturation. Mutations in the Shank 3 gene have been associated with neuropsychiatric diseases, including autism spectrm disorder.
Purified by Protein A chromatography
0.5 mg/mL
Monoclonal
N367/62
IgG2a
ICC, IHC
Mouse
Shank3 Prosap2
190 kDa
Fusion protein amino acids 538-626 (SH3 domain) of rat Shank3 (accession number Q9JLU4) produced recombinantly in E. Coli
Mouse, Rat
AB_2940168
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL490 Ex: 491 nm, Em: 515 nm
Does not cross-react with Shank1 or Shank2
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
12 months from date of receipt
Shipped on ice packs
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
UniProt (Human): Q9BYB0
UniProt (Immunogen Species): Q9JLU4
UniProt (Immunogen Species): Q9JLU4