Anti-TMEM119 Antibody FL490 Conjugate (L128/43)

Name: Anti-TMEM119 Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-512-FL490
Price: 460.0 USD
Availability: InStock

Our Anti-TMEM119, OBIF mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L128/43. It detects mouse TMEM119, OBIF, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Mouse

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

550

594

650

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Data Sheet

SKU: 75-512-FL490

Volume: 200 µL

Variant

Price:

$460.00

Quantity:

Product Details

Target

TMEM119, OBIF

Target Description

TMEM119, is a plasma membrane protein first identified because of its role in the differentiation of osteoblasts (Kanamoto et al., 2009). However TMEM119 is also known to be a specific marker of microglia, the tissue-resident macrophages of brain and spinal cord (Bennett et al., 2016). Unlike other microglia markers, TMEM119 expression readily distinguishes resident microglia from blood-derived macrophages, making it a highly specific microglia marker. In healthy brain microglia are the resident immune cells where they act to neutralize pathogens, clear dead and dying cells, and prune synaptic connections. However, in neurodegenerative disease microglia can actually promote neuronal degeneration through reduced phagocytic clearance and increased pro-inflammatory effects. Our anti-TMEM119 antibody is a highly specific microglial marker for mouse TMEM119 and works by western blot and immunocytochemistry.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

L128/43

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

TMEM119

Molecular Weight

30 kDa

Antigen

Fusion protein amino acids 113-280 (cytoplasmic C-terminus) of mouse Tmem119

Species Reactivity

Mouse

Antibody Registry ID

AB_2940700

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

TMEM119, OBIF

UniProt Details

UniProt (Immunogen Species): Q8R138

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Anti-TMEM119 Antibody FL490 Conjugate (L128/43)

SKU: 75-512-FL490

Product Details

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