Our Anti-ICK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N451/73. It detects mouse and rat ICK, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
Serine/threonine-protein kinase ICK is encoded by the gene Ick. Ick is a member of the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. Ick has an essential role in ciliogenesis. Ick is envolved in the control of ciliary length by regulating the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. Ick is highly expressed in the colon and lungs, with lower levels of expression in the heart, esophagus, stomach, small intestine, and ovaries. Diseases associated with Ick include endocrine-cerebroosteodysplasia, juvenile myoclonic epilepsy 10, and juvenile myoclonic epilepsy 1.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N451/73
IgG1
ICC, IHC, WB
Mouse
Ick
70 kDa
Fusion protein amino acids 290-629 (C-terminus) of mouse ICK (accession number Q9JKV2) produced recombinantly in E. Coli
Mouse, Rat
AB_2576198
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Unconjugated
No cross-reactivity reported
Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
