Anti-LRRTM4 Antibody (N205B/22)

Name: Anti-LRRTM4 Antibody
Brand: NeuroMab
SKU: 75-261
Price: 319.0 USD
Availability: InStock

Our Anti-LRRTM4 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N205B/22. It detects human, mouse, and rat LRRTM4, and is purified by Protein A chromatography. It is great for use in ICC, WB.

Adult rat brain membrane immunoblot.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-261

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

LRRTM4

Target Description

Leucine Rich Repeat Transmembrane Neuronal 4 is encoded by the gene LRRTM4. LRRTM4 is a member of the LRRTM family. LRRTM4 may play a role in the development and maintenance of the vertebrate nervous system. LRRTM4 exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation. LRRTM4 is expressed in neuronal tissues. No disorders were found to be associated with LRRTM4.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N205B/22

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

LRRTM4 UNQ3075/PRO9907

Molecular Weight

70 kDa

Antigen

Synthetic peptide amino acids 470-484 (ARESERQMNSPLQEY, cytoplasmic C-terminus) of human LRRTM4 (accession number Q86VH4)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10674580

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Reacts with both Long and Short isoforms

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Leucine-rich repeat transmembrane neuronal protein 4

UniProt Details

UniProt (Human): Q86VH4
UniProt (Immunogen Species): Q86VH4

Product Specific References for Applications and Species

Immunocytochemistry: Rat
Immunohistochemistry: Mouse
Immunoprecipitation: Mouse
Western Blot: Mouse

Immunocytochemistry: Rat
PMID	Dilution	Publication
23911103	not listed	de Wit, J., et al. 2013. Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development.. Neuron, 696-711.

Immunohistochemistry: Mouse
PMID	Dilution	Publication
35022233	not listed	Kim, J., et al. 2022. LRRTM3 regulates activity-dependent synchronization of synapse properties in topographically connected hippocampal neural circuits. PNAS USA, .

Immunoprecipitation: Mouse
PMID	Dilution	Publication
31974009	not listed	Sinha, R., et al. 2020. LRRTM4: A novel regulator of presynaptic inhibition and ribbon synapse arrangements of retinal bipolar cells. Neuron, 1007-1017.

Western Blot: Mouse
PMID	Dilution	Publication
35662394	1:1000	Dhume, S.H., et al. 2022. Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits. Elife, e64742.
31995730	1:1000	Roppongi, R.T., et al. 2020. LRRTMs organize synapses through differential engagement of neurexin and PTPσ. . Neuron, 108-125.
31974009	1:1000	Sinha, R., et al. 2020. LRRTM4: A novel regulator of presynaptic inhibition and ribbon synapse arrangements of retinal bipolar cells. Neuron, 1007-1017.

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Anti-LRRTM4 Antibody (N205B/22)

SKU: 75-261

Product Details

Product Specific References for Applications and Species

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